Korea Institute of Science and Technology

Other

University-Industry Cooperation Group of Kyung Hee University

Dongwoo Syntech Co., Ltd

Lee, Jae Yeol

Jae Yeol Lee

Yong Sup Lee

Hokoon Park

Eun-Rhan Woo

Dae Hwan Suk

Kyung-Tae Lee

Hyewhon Rhim

Dong J Choo

Sun Ho Jung

Young Deuk Kim

Hyoung Ja Kim

Chun Rim Oh

Chang Bae Jin

Chang Soo Yook

Min Jeoung Son

Hyeowhon Rhim

Yong Sup Dept Of Pharmaceutical Science Lee

Dong Joon Choo

The holder for organization according to the present invention comprises a main body configured to have an accommodation space for accommodating a to-be-organized object therein and an entrance formed on one side of the main body for introducing or withdrawing the to-be-organized object into the accommodation space; an opening/closing unit configured to close the entrance and open the entrance while sliding when pressed by the to-be-organized object; and a holder unit configured to press and hold the to-be-organized object passing through the opening/closing unit and accommodated in the accommodation space toward the opening/closing unit.

Holder for organization

The present invention relates to a holding magnetizer, which can: maintain a strong magnetic force even if away from the tip of a driver bit, regardless of the length of the bit, when mounted on the bit so as to perform screw work; reduce or remove magnetic force when the magnetic force needs to be weakened in accordance with work circumstances; use a screw holding ability so as to prevent a screw from being separated from the bit and being lost; and remove iron powder, generated by screw abrasion during work, when the iron power is attached to the tip of the driver bit.

Holding magnetizer

The present invention relates to a depth adjustment stopper for a drill bit. The present invention enables easy workability during forming of a drilled groove having a fixed depth into a material by means of a drill bit. The depth adjustment stopper coupled to the drill bit is supported by means of the tension of a spring. Therefore, the depth adjustment stopper is prevented from shaking or being pushed.

Depth adjustment stopper for drill bit

A 3,4-dihydroquinazoline derivative or a pharmaceutically acceptable salt thereof and a composition containing the same are provided. The 3,4-dihydroquinazoline derivative or a pharmaceutically acceptable salt thereof show activities of blocking an intracellular influx of calcium ions acting as a secondary signal essential to the proliferation and growth of cancer cells, thereby inducing the cell cycle arrest of cancer cells, and eventually reinforcing the efficacy of existing anti-cancer drugs. A combination comprising the above compound and another anti-cancer drug is also provided.

3,4-dihydroquinazoline derivative and combination comprising the same

The present invention relates to anextract, a fraction thereof and the active compounds isolated therefrom, which are effective for the treatment, prevention and improvement of hyperuricemia or gout. Theextract, the fraction thereof and 6'-O-caffeoylampelopsisionoside, 6&#x2032;-O-caffeoylroseoside, 6&#x2032;-O-caffeoylsonchuinoside C, 6&#x2032;-O-caffeoyldihydrosyringin and glehnoside as the active compounds isolated from the fraction according to the present invention have substantial effect of inhibiting production of uric acid and decreasing its concentration. Accordingly, theextract, the fraction thereof and the active compounds isolated therefrom the fraction according to the present invention can be effectively used as an active ingredient of a drug, health food, etc. for the treatment, prevention and improvement of such as hyperuricemia or gout, which are diseases induced by increased level of uric acid.

[object Object]

Disclosed are 3,4-dihydroquinazoline derivatives of formula (I), a process of preparing them and a pharmaceutical composition including them. The 3,4-dihydroquinazoline derivatives of the present invention have excellent T-type calcium channel blocking effect and anti-cancer activity 

3,4-dihydroquinazoline derivatives

The present invention relates to 3,4-dihydroquinazoline derivatives as T-type calcium channel blockers and a method of preparing the same. The present invention further relates to a composition comprising the same. The composition comprising the 3,4-dihydroquinazoline derivatives of the present invention can be effectively used for preventing and treating angina pectoris, high blood pressure, myocardial disease, pain and epilepsy by blocking the T-type calcium channel.

3,4-dihydroquinazoline derivatives as T-type calcium channel blockers and method of preparing the same

A 3-ammoniopropenyl cephalosporin of the following formula (I): ##STR1## wherein P is hydroxylated alicyclic or aliphatic amines such as meso-3,4-dihydroxy-1-methylpyrrolidine, (3S,4S)-3,4-dihydroxy-1-methylpyrrolidine, (3R,4R)-3,4-dihydroxy-1-methylpyrrolidine, rac-3,4-trans-dihydroxy-1-methylpyrrlidine, (2S,4R)-4-hydroxy-1-methyl-2-pyrrolidinemethanol, N-methyl-bis(2-hydroxyethyl)amine, 3,4-cis-dihydroxy-1-methylpiperidine, 3,4-trans-dihydroxypiperidine, 4-hydroxy-1-methylpiperidine, 2-hydroxymethyl-1-methylpiperidine, or tropine, or a pharmaceutically acceptable salt thereof, exhibits good anti-bacterial activities against a wide variety of Gram-positive and Gram-negative bacteria; and a process for the preparation thereof.

3-ammoniopropenyl cephalosporin compounds as antibacterial agents and

3-ammoniopropenyl cephalosporin compounds as antibacterial agents

Quaternary ammoniocephalosporins of formula(I) wherein Q.dbd.CH or N, P.dbd.hydroxylated amine or hydroxylated heterocyclylamines including N-methyl-bis(2-hydroxyethyl)amine, rac-3,4-trans-dihydroxy-1-methylpyrrolidine, (3S, 4S)-3,4-dihydroxy-1-methylpyrrolidine, (3R,4R)-3,4-dihydroxy-1-methylpyrrolidine, meso-3,4-dihydorcy-1-methylpyrrolidine, (2S, 4R)-4-hydroxy-1-methyl-2-pyrrolidinemethanol 3,4-cis-dihydroxy-1-methylpiperidine, 3,4-trans-dihydroxy-1-methylpiperidine, or tropine, and preparation methods are disclosed. ##STR1##

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Seoul, South Korea

Jae Yeol Lee