The Catholic University of Korea Industry-academic Cooperation Foundation

Samsung Display Co., Ltd.

The Catholic University of Korea Industry-academic Cooperation Foundation, Catholic Univ. of Korea Songeui Campus

The Catholic University of Korea Industry-academic Corporation Foundation

Jae-Kyung Kim

Sung-Hee Lee

Mi-La Cho

Min-Jung Park

Seon-Yeong Lee

Dong-Yun Shin

Hye-Jin Son

Eun-Kyung Kim

Chul-Woo Yang

Eun-Ji Yang

Eun Kyung Kim

Min-Woo Kim

Il-Nam Kim

Hae-Yun Choi

Soo-Min Baek

Sung-Hwan Park

Eun-Jung Lee

Jong-Young Choi

Seung-Hun Lee

Eun Ji Yang

Seong-Hyeok Park

Chul- Woo Yang

The present invention relates to a biguanide derivative compound capable of effectively preventing and treating immune diseases. The biguanide-based derivative compound according to the present invention inhibits the generation of IL-17 and TNF-&#x3b1;, which are inflammatory cytokines, increases the activity of regulatory T cells having an immunomodulatory function, and exhibits excellent therapeutic effects in animal models of immune diseases. Accordingly, the biguanide-based derivative compound can be usefully used as an immunosuppressant or a pharmaceutical composition capable of preventing or treating various immune diseases, such as autoimmune diseases, inflammatory diseases, and transplant rejection, caused by the dysregulation of immune responses.

Pharmaceutical composition for preventing or treating immune diseases or inflammatory diseases, containing biguanide derivative compound as active ingredient

Provided is a novel compound capable of effectively preventing and treating immune diseases and a use thereof. The novel compound of the present subject matter has effects of inhibiting the production of inflammatory cytokines, increasing the activity of regulatory T cells having immunoregulatory functions, inhibiting the production of auto-antibodies to regulate excessive immune responses, and inhibiting the differentiation of osteoclasts, and thus can be used for treating immune diseases, such as autoimmune disease, inflammatory disease, and transplant rejection diseases, which are caused by abnormal regulation of various kinds of immune response.

Compound having immune disease treatment effect and use thereof

The daurinol compound according to the present invention exhibits excellent therapeutic effects on arthritis and inflammatory bowel diseases by having an excellent activity in inhibiting the generation of IL-17 and TNF-&#x3b1;, which are inflammatory cytokines causing inflammation, and can alleviate transplant rejection by inhibiting the proliferation of alloreactive T cells and increasing regulatory T cells; therefore, the daurinol compound according to the present invention can be used as a pharmaceutical composition capable of treating and preventing immune diseases. In addition, being a natural substance derived from the Mongolian medicinal plantor, the daurinol compound according to the present invention does not cause cytotoxicity and thus may be used as a composition for a functional health food capable of preventing and remedying immune diseases.

Composition for treating immune diseases containing daurinol compound as active ingredient

A display apparatus capable of implementing high luminance and high contrast ratio (C/R) may include a first substrate, a second substrate disposed on the first substrate so as to face the first substrate and having a plurality of pixel regions defined therein, and a plurality of color filters formed on the plurality of pixel regions of the second substrate, each color filter having one or more holes formed therein.

Display apparatus

Growing community of inventors

Cheonan-si, South Korea

Jae-Kyung Kim