Korea Institute of Science and Technology

Hyundai Motor Company

Kia Motors Corporation

Jae Kyun Lee

Ae Nim Pae

Yong Seo Cho

Hyunah Choo

Kyung Il Choi

Hyewhon Rhim

Gyo Chang Keum

Seon Hee Seo

Youngsoo Kim

Dong Jin Kim

Hee Sup Shin

Eun Joo Roh

Yong Koo Kang

Ghil Soo Nam

Kye Jung Shin

Sun Joon Min

Eunice Eun-Kyeong Kim

Key-Sun Kim

Hesson Chung

Ghilsoo Nam

Dong Yun Shin

Hye Jin Chung

Kee Dal Nam

Hoh Gyu Hahn

Yoon Jee Kim

Woong Seo Park

Hye Ran Kim

Chan Seong Cheong

Kee Hyun Choi

Jung Hyun Kim

Yun Kyung Kim

Jae Kyu Lee

Soon Bang Kang

You Seung Kim

Hyun Ah Choo

Chi Man Song

Sung Su Lim

Eun Kyoung Bang

Ji Yeong Kim

Cheolju Lee

Eun Jeong Lim

Young Wook Son

Myung Hee Son

Jin Ri Hong

Ahmed A Elbatrawy

You Na Oh

Disclosed are a compound with near-infrared fluorescence that selectively binds to tau aggregates, a method for preparing the same, a tau-targeting near-infrared fluorescent probe including the compound, a composition for detecting a tau fiber protein containing the near-infrared fluorescent probe as an active ingredient, and the use of the composition for the diagnosis of tauopathy. In particular, the compound does not bind to an amyloid beta protein and has high selectivity to a tau aggregate, specifically reported as an etiology of the initial state of tauopathy, thus being useful as a near-infrared fluorescent detector for detecting a tau fiber protein for early diagnosis of a tauopathy including Alzheimer's disease.

Compounds useful as near-infrared fluorescent probes selectively binding to tau aggregates and method of preparing the same

The present disclosure provides a timing belt cover assembly for a vehicle capable of being mounted in a compact structure at a front side of an engine. The timing belt cover assembly includes: a timing belt cover installed at a front side of an engine and having an opening formed in a portion of a front surface thereof; and a support bracket installed to close the opening of the timing belt cover.

Timing belt cover assembly for vehicle

Disclosed herein are an N-(pyrazolylmethyl)arylsulfonamide derivative useful as a calcium ion channel blocker, a pharmaceutically acceptable salt thereof, and the medicinal use thereof as a therapeutic agent using its calcium ion channel blocking effect.

Compounds capable of inhibiting voltage gated calcium ion channel, and pharmaceutical compositions comprising the same

The present invention relates to a method for preparing tetrabenazine (TBZ) and dihydrotetrabenazine (DTBZ), and more specifically to a method for preparing tetrabenazine (TBZ) and dihydrotetrabenazine (DTBZ) by using simple and short reaction processes of using 6,7-dimethoxy-1,2,3,4-tetrahydroisoquinoline and 4-methyl-2-(3-(trimethylsilyl)prop-1-ene-2-yl)pentane as starting materials to sequentially perform an alkylation reaction, an Aza-Prins cyclization reaction in the presence of an oxidant and an oxidation reaction.

Method of preparing tetrabenazine and dihydrotetrabenazine

Provided is a 2-(substituted ethynyl)quinoline derivative having an mGluR5 antagonistic activity and pharmaceutically acceptable salts thereof. The compound of the present invention can be useful as a medicament for treating and preventing mGluR5 receptor-mediated diseases such as Alzheimer's disease, senile dementia, Parkinson's disease, L-DOPA-induced dyskinesia, Huntington's chorea, amyotrophic lateral sclerosis, multiple sclerosis, schizophrenia, anxiety disorder, depression, neuropathic pain, drug dependence, fragile X syndrome, autism, migraine and gastroesophageal reflux disease (GERD).

2-(substituted ethynyl)quinoline derivatives as mGLUr5 antagonists

Disclosed are novel imidazolylalkylcarbonyl derivatives useful as calcium channel modulators and a preparation method of the same. Also disclosed is a method for the treatment of diseases by administering the above compounds based on their inhibitory activity against calcium channel.

Imidazolylalkylcarbonyl derivatives as calcium channel modulators and preparation method thereof

The present invention relates to pyrazolylmethylamine-piperazine derivatives and their pharmaceutically acceptable salts effective as calcium channel modulators and a method of manufacturing the same. The present invention also relates to the medicinal use of the above compounds as therapeutic treatment of diseases due to their effect as calcium channel modulators.

Pyrazolylmethylamine compounds as calcium channel modulators and preparation method thereof

Disclosed are isoindolinone derivatives, represented by Chemical Formula 1, having inhibitory activity against T-type calcium channels, pharmaceutically acceptable salts thereof, a preparation method thereof, and a pharmaceutical composition comprising the same as an active ingredient. 

Isoindolinone derivatives having inhibitory activity against T-type calcium channel and method for preparation thereof

Disclosed are cis-2,6-disubstituted tetrahydropyran derivatives represented by Chemical Formula 1 and a preparation method thereof. The tetrahydropyran derivatives can be prepared by Prins-reacting tetrahydropyran derivatives with homopargylicalcohol derivatives in the presence of trimethylsilyltriflate. The tetrahydropyran derivatives with cis-substituents at both C2 and C6 positions of the tetrahydropyran ring are useful as intermediates for use in the synthesis and development of therapeutically effective, naturally occurring compounds.  (wherein, R, Rand Rare as defined in the specification.).

Cis-2, 6-disubstituted tetrahydropyran derivatives and preparation method thereof

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Seoul, South Korea

Jae Kyun Lee