Newtree Co., Ltd.

Other

Biocare Co., Ltd.

Yonsei University

Aat Costech Co., Ltd.

Newtree Industry Co., Ltd.

Hwang, Jae-kwan

Jae-Kwan Hwang

Do Un Kim

Heechul Chung

Mi-Bo Kim

Tae Yoon Kim

Doun Kim

Jae Youn Chung

Hee-Chul Chung

Kyu-Lee Han

Jae-Youn Chung

Bo Kyung Sa

Changhee Kim

Jae-Young Lee

Do Hun Kim

Jae Young Lee

Jeong Hwan Kim

Kyung-Min Park

Eun Jung Choi

Jeong-Hwan Kim

Chang Hee Kim

Myung Suk Kim

Jong-hee Sohn

Young Sun Han

Hae Ji Lee

Hee Chul Chung

Ga Hui Oh

Ah-Jin Kim

Jeong-Han Choo

Jae-Seok Shim

Do-Un Kim

Hyun In Oh

Yi Young Kwon

The present invention relates to a composition for preventing and treating muscle diseases or improving muscular function, containing aextract. More specifically, the present invention relates to: a pharmaceutical composition for preventing and treating muscle diseases, containing aextract; a food composition for preventing muscle diseases or improving muscular function; or a cosmetic for improving muscular function. Theextract of the present invention increases muscle formation by inducing muscular protein synthesis and muscle cell differentiation. Therefore, the extract is a natural product so as to be used safely without side effects, thereby being usable as an active ingredient of a pharmaceutical, food, or cosmetic composition exhibiting an excellent effect in preventing and treating muscle diseases or improving muscular function.

Composition for preventing and treating muscle diseases or improving muscular function, containing platycodon grandiflorum extract

The present invention relates to a composition for preventing and treating muscle diseases or improving muscular function, containing, as an active ingredient, at least one selected from the group consisting of morusin, kuwanon G, and a Mori Cortex Radicis extract. The Mori Cortex Radicis extract, morusin, or kuwanon G, according to the present invention, has an effect of remarkably enhancing muscular function by increasing the expression of p-mTOR protein involved in muscular protein synthesis, inhibiting the expression of mRNAs of MuRF-1 and atrogin-1 involved in muscular protein degradation, and increasing the expression of mRNAs of MyoD and myogenin involved in muscular differentiation. In addition, the present invention is a natural product so as to be used safely without side effects, thereby being usable in drugs, food, or cosmetics.

Methods for treating muscle wasting and degeneration diseases

The present invention relates to a composition for muscle function improvement or exercise ability enhancement, the composition including kirenol, aextract, or a fraction of theextract as an active ingredient. Kirenol, theextract containing kirenol, or theextract fraction according to the present invention has an excellent effect of increasing muscle mass by increasing the protein expression of p-mTOR, which is a major gene concerned with muscle functions. Also, kirenol, theextract containing kirenol, or theextract fraction according to the present invention has an effect of remarkably enhancing exercise ability by increasing the protein expression of PGC-1&#x3b1;, which is a major gene concerned with exercise ability. In addition, the present invention is a natural product, and thus is safe for use without side effects and can be used as a medicine or food.

Composition including kirenol or siegesbeckia herba extract for muscle function improvement or exercise ability enhancement

The present invention relates to a pharmaceutical composition containingWall. Ex. Baker extracts for treating muscle diseases, and more specifically to a pharmaceutical composition containing, as an active ingredient,Wall. Ex. Baker extracts or flavone compound isolated therefrom for treating muscle diseases or a dietary composition for improving muscle function.Wall. Ex. Baker extracts or flavone compound isolated therefrom according to the present invention reduces protein catabolism in the muscles and increases muscle cell differentiation and anabolism, and is thus effective for preparing pharmaceutical composition for treating muscle diseases and dietary composition for improving muscle function.

Use of Kaempferia parviflora wall. ex. baker extracts or flavone compound for preventing or treating muscle diseases, or improving muscle function

Use of kaempferia parviflora wall. ex. baker extracts or flavone compound for preventing or treating muscle diseases, or improving muscle function

The present invention relates to a pharmaceutical composition containing flavone compound as an active ingredient for treating obesity, and more specifically to a pharmaceutical composition for preventing or treating obesity and a dietary composition for preventing or reducing obesity containing 5,7-dimethoxyflavone or 5,7,4'-trimethoxyflavone. The compound according to the present invention inhibits adipogenesis, and reduces expression of the key transcription factors (SREBP1c and C/EBP) related to lipogenesis and of enzyme proteins (FAS and ACC) related to adipogenesis, and thus is effective in preventing or treating obesity.

Use of flavone compound for prevention or treatment of obesity

The present invention relates to the novel use of panduratin derivatives or an extract offor enhancing muscle mass growth, fighting fatigue and enhancing exercise performance, and more particularly to a composition for promoting an increase in muscles, anti-fatigue composition and a composition for enhancing muscle mass growth and recovery from fatigue to improve exercise performance, the composition comprising a panduratin derivative or a salt thereof or an extract ofas an active ingredient, and to a method for enhancing muscle mass growth, of treating or preventing fatigue syndrome and enhancing exercise performance, the method comprising a panduratin derivative or a salt thereof or a extract ofto a subject in need thereof. A panduratin derivative or a salt thereof or an extract ofof the present invention may be used without side effect and has the effect of increasing the expression of PPAR-&#x3b4; in muscles to increase muscle mass, promoting recovery from fatigue and increase mobility, thereby improving exercise performance.

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The present invention relates to the novel use of panduratin derivatives or an extract offor enhancing muscle mass growth, fighting fatigue and enhancing exercise performance. A panduratin derivative or a salt thereof or an extract ofof the present invention may be used without side effect and has the effect of increasing the expression of PPAR-&#x3b4; in muscles to increase muscle mass, promoting recovery from fatigue and increase mobility, thereby improving exercise performance.

The present invention relates to the use of lignan compounds for treating or preventing an inflammatory disease. More particularly, it relates to a method for preventing or treating an inflammatory disease, comprising administering to a subject in need thereof an effective amount of macelignan represented by Chemical Formula I or a pharmaceutically acceptable salt thereof. The lignan compound has the effect of inhibiting inflammatory reactions by inhibiting the production or expression of inflammation mediators NO, iNOS, PGE, COX-2 and TNF-&#x3b1; and by treating or preventing inflammatory disease in vivo. Accordingly, the lignan compound or aextract will be highly useful for the treatment or prevention of an inflammatory disease.

Use of lignan compounds for treating or preventing inflammatory disease

The present invention relates to a novel use of a panduratin derivative or aextract. More specifically, the invention relates to a composition for preventing and treating/relieving a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes, containing a panduratin derivative represented by Chemical Formula 1, 2 or 3 or aextract as an active ingredient, a method for treating a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes, by administering an effective amount of the panduratin derivative or theextract to a subject in need thereof, and a use of the panduratin derivative or theextract to prepare a reagent for preventing and treating/relieving a metabolic disease selected from a group consisting of obesity, hyperlipidemia, hypercholesterolemia and diabetes.

The present invention relates to a method and composition for treating acne using lignan compounds represented by Formula 1. More particularly, the invention relates to an antibacterial composition against acne-causing bacteria, containing lignan compounds represented by Formula 1, as well as a method for treating acne using the same. The lignan compounds represented by Formula 1 are excellent not only in the antibacterial activity of inhibiting the growth of acne-causing bacteria, but also in thermal stability. Accordingly, the lignan compounds may be useful as antibacterial agents against the acne-causing bacteria, and acne treatment agents.

Method and composition for treating acne using lignan compounds

The present invention relates to a novel use of lignan compounds, which are isolated and purified from nutmeg or the aril of nutmeg for anti-wrinkle, and more particularly, the present invention relates to a novel use for anti-wrinkle of an extract of the nutmeg or an extract of the aril of the nutmeg, fragrin A, austobailignan 7, licarin E, and macelignan. The extracts and lignan compounds of the present invention have activities in suppressing collagen degradation enzyme-1 (MMP-I, matrix metalloprotei-nase-1) and formation of new collagen (type-1 procollagen), thereby having effect on inhibitng wrinkle caused by photoaging. Accordingly, the extracts and lignan compounds of the present invention may be useful for preventing or treating wrinkle caused by photoaging.

Use of lignan compound for anti-wrinkle treatment

Disclosed is a method for treating PPAR (peroxisome proliferator activated receptor)-mediated diseases, such as diabetes mellitus, which includes administering to a subject an effective amount of macelignan represented by the following Formula (I): or a pharmaceutically acceptable salt thereof.

Method for treating conditions mediated by PPAR using macelignan

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Gyeonggi-do, South Korea

Jae-Kwan Hwang