Dong-a Pharm. Co., Ltd.

Dong-a St Co., Ltd.

Dong-a Pharmaceuticals Co. Ltd.

Jae Keol Rhee

Tae Ho Lee

Chong Hwan Cho

Sung Hak Choi

Weon Bin Im

Moo Hi Yoo

Seong Jin Park

Jun Ho Choi

Soon Hoe Kim

Mi Won Son

Mi Rim Jin

Sang Jin Choi

Si Young Sung

Moon Sung Kim

Dae Won Cha

Yong Jik Kim

Nam Joon Baek

Jin Pub Son

Hong Gyu Lim

Tao Ho Lee

The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad spectrum of bacteria and lower toxicity. The prodrugs, prepared by reacting the compound having hydroxyl group with amino acid or phosphate, have an excellent efficiency on solubility thereof against water. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such asand, anaerobic microorganisms such asand Clostridia, and acid-resistant microorganisms such asand. Accordingly, the compositions comprising the oxazolidinone are used in an antibiotic.

Oxazolidinone derivatives

The present invention relates to herbal extracts ofSemen,Tuber,Seed, andSemen, and a composition containing the same for treating and preventing gastrointestinal motility disorder. The extracts of the present invention have a remarkable effect of promoting gastrointestinal motility through HTreceptor antagonism and/or HTreceptor antagonism.

Extract of herbal and composition containing the same

The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad spectrum of bacteria and lower toxicity. The prodrugs, prepared by reacting the compound having hydroxyl group with amino acid or phosphate, have an excellent efficiency on solubility thereof against water. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such as, Staphylococci, Enterococci and Streptococci anaerobic microorganisms such asand Clostridia, and acid-resistant microorganisms such asand. Accordingly, the compositions comprising the oxazolidinone are used in an antibiotic.

The present invention provides novel crystalline forms Dand Dof [R&#x2014;(R*,R*)]-2-(4-fluorophenyl)-&#x3b2;,&#x3b4;-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemicalcium salt, and hydrates thereof. The crystalline forms Dand Dhave X-ray powder diffraction peaks described in FIGS.and, respectively. Further, the present invention provides processes for preparing the crystalline forms and pharmaceutical compositions comprising the crystalline forms. The crystalline forms can be produced on a commercial scale and exhibit excellent stability.

Crystal forms of pyrrolylheptanoic acid derivatives

The present invention relates to novel derivatives of oxazolidinone, a method thereof and pharmaceutical compositions comprising the derivatives for use in an antibiotic. The oxazolidinone derivatives of the present invention show inhibitory activity against a broad spectrum of bacteria and lower toxicity. The prodrugs, prepared by reacting the compound having hydroxyl group with amino acid or phosphate, have an excellent efficiency on solubility thereof against water. Further, the derivatives of the present invention may exert potent antibacterial activity versus various human and animal pathogens, including Gram-positive bacteria such as Staphylococi, Enterococci and Streptococi, anaerobic microorganisms such asand Clostridia, and acid-resistant microorganisms such asand. Accordingly, the compositions comprising the oxazolidinone are used in an antibiotic.

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Kyonggido, South Korea

Jae Keol Rhee