Panagene Inc.

Jae Jin Choi

Jin Woo Kim

Jong Chan Lim

Hyunil Lee

Sung Kee Kim

Hee Kyung Park

Goon Ho Joe

Jung Hyun Min

Su Nam Kim

Yong Tae Kim

Hye Yeon Kim

Jun Ho Park

Serka Kim

Bong Ho Um

Ji Hye Yoon

In Seong Wo

Sung Jin Ha

Jin Won Yun

Disclosed is a probe mixture for real-time detection of target nucleic acids comprising at least one detection probe and at least one clamping probe for inhibiting amplification of wild type genes or unwanted genes, a kit using the same and a method for real-time detection of target nucleic acids using the mixture and the kit.

Method for the detection of multiple target nucleic acids using clamping probes and detection probes

The present invention relates to a peptide nucleic acid (PNA) conjugated with multi-amine linkers, and a method to prepare the same and utilization thereof. More specifically, the method is characterized by conjugating monomers having multi-amine functionality sequentially at a PNA terminal, and effectively immobilizing the PNA conjugated with multi-amine linkers on a solid surface. A PNA array prepared using the PNA conjugated with multi-amine linkers exhibits improved sensitivity and specificity of signals for detecting target nucleic acids as compared to a PNA array using PNA probes having only one amine group. The PNA conjugated with multi-amine linkers can be utilized in nucleic acid detecting devices or kits for gene diagnosis such as PNA microarrays, PNA chips, PNA field-effect transistors and impedance detectors.

Peptide nucleic acids conjugated with multi-amine linkers and nucleic acid detecting device using the same

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Daejeon, South Korea

Jae Jin Choi