Northwestern University

Jae-Hyung Jang

Lonnie D Shea

Tatiana Segura

Zain Bengali

Yang Yang

Brian C Anderson

Angela Kaye Pannier

Kevin Whittlesey

Peter Chung

Christopher Rives

Lonnie L Shea

Laura De LaPorte

The invention is directed to scaffolds containing porous polymer material prepared by a process of gas foaming/particulate leaching and a wet granulation step prior to gas foaming and particulate leaching, particularly having a characteristic interconnected pore structure, as well as sustained release of protein, DNA or cells, and to methods for using such porous polymer material for preparation of scaffolds, particularly for tissue engineering.

Biodegradable scaffolds and uses thereof

A system and methods for controlled gene delivery comprising condensed nucleic acids complexed with polylinkers, wherein the complexes are covalently and/or non-covalently bound to the surface of a substrate capable of supporting cell adhesion. The gene delivery system achieves temporal and spatial control of nucleic acid delivery to a target cell or cells through control of complex density on the surface of the support substrate, and reversibility of the attachment of the polylinker to the support substrate. The system and method of the invention can be used to create spatial patterns of gene expression, and in tissue engineering, high throughput screening, and gene therapy applications.

Controlled surface-associated delivery of genes and oligonucleotides

Growing community of inventors

Richmond, CA, United States of America

Jae-Hyung Jang