Korea Research Institute of Bioscience and Biotechnology

Jae-Hyuk Jang

Bo Yeon Kim

Jong Seog Ahn

Nak Kyun Soung

Sun Ok Kim

In Ja Ryoo

Joonsung Hwang

Krisada Sakchaisri

Hee Gu Lee

Kyung Ho Lee

Hyuncheol Oh

Mija Ahn

Hyunjoo Cha

Sung-Kyun Ko

Thimmegowda Nr

InJa Ryoo

JunPhil Jang

Chan-Mi Park

Yukihiro Asami

Jiyun Mun

Ramegowda Thimmegowda Naraganahalli

Srinivasrao Ganipisetti

The present invention relates to a composition for preventing, alleviating or treating inflammatory diseases, comprising, as an active ingredient, an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof. an acylhydrazone derivative compound, a stereoisomer thereof or a pharmaceutically acceptable salt thereof, of the present invention, effectively inhibits inflammatory cytokines and inflammatory signaling pathways, thereby effectively alleviating symptoms of inflammatory diseases such as dermatitis. Therefore, the composition according to the present invention may be effectively used for the prevention, alleviation or treatment of inflammatory diseases.

Anti-inflammatory composition comprising acylhydrazone derivative

The present invention relates to (E)-ethyl 2-(2-methyl-3-((2-(naphtho[2,1-b]furan-2-carbonyl)hydrazono)methyl)-1H-indol-1-yl)acetate as a novel tubulin polymerization inhibitor and a method for synthesizing the same. The compound of the present invention can inhibit mitosis and induce apoptosis and thus be used as an anticancer agent, by binding to tubulin to inhibit microtube polymerization. According to the synthesis method of the present invention, the reaction is simplified and the efficiency is 60% or higher, leading to a very high yield, thereby providing an effective synthesis method.

Tubulin polymerization inhibitor and method for synthesizing same

The present invention relates to ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate, the novel mitosis inhibitor. The said ethyl(2-methyl-3{(E)-[(naphtho[2,1-b]furan-2-ylcarbonyl)hydrazono]methyl}-1H-indole-1-yl)acetate not only induces apoptosis by inhibiting tubulin polymerization in the course of mitosis but also displays an excellent anticancer effect in the multi-drug resistant cancer cells, so that it can be effectively used for the treatment of cell proliferative disease including various cancers.

[object Object]

The present invention relates to novel fusarisetin compounds separated fromsp. FN080326 and having an anticancer activity, and to the use thereof. In detail, novel fusarisetin compounds separated and purified fromsp. FN080326, which is in turn separated from a soil sample, have an inhibitory activity on the proliferation and transfer of cancer cells such as breast cancer cells, liver cancer cells or myeloid leukemic cells. Therefore, the compounds can be effectively used for anticancer compositions containing the compounds as active ingredients.

Fusarisetin compounds, and use thereof

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Daejeon, South Korea

Jae-Hyuk Jang