Research Cooperation Foundation of Yeungnam University

Industry Academic Cooperation Foundation of Yeungnam University

Jae Hui Been

You Ra Kang

Jung Ae Kim

Byeong Seon Jeong

Dong Guk Kim

Tae Gyu Nam

You Jin Jin

Hyun Ji Lee

Sushil Chandra Regmi

Jaya Gautam

An amidopyridinol derivative or a pharmaceutically acceptable salt thereof, and a pharmaceutical composition including the amidopyridinol derivative as an active component represented by Chemical Formula 1 or a pharmaceutically acceptable salt thereof have an antiangiogenic effect in a chorioallantoic membrane model, and thus are useful as an agent for preventing or treating diseases associated with angiogenesis, and also have a colitis-inhibitory effect in a model of inflammatory bowel diseases, and thus are useful as an agent for preventing or treating inflammatory bowel diseases. Upon inoculation of lung cancer cells in a chorioallantoic membrane model, the amidopyridinol derivative of Chemical Formula 1 or the pharmaceutically acceptable salt thereof inhibits angiogenesis and tumor growth that are caused by tumorigenesis, and also inhibits the activity of cathepsin S that plays an important role in metastasis and invasion of cancer, and thus is useful as an inhibitor of cancer growth and metastasis.

Amidopyridinol derivative or pharmaceutically acceptable salt thereof and pharmaceutical composition comprising same as active component

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Daegu, South Korea

Jae Hui Been