Korea Research Institute of Chemical Technology

Dongbu Hannong Chemical Co., Ltd.

Dongbu Hitek Co., Ltd.

Moghu Research Center Ltd

Jae Chun Woo

Jae Wook Ryu

Young Kwan Ko

Dong Wan Koo

Dae Whang Kim

Hae Sung Chang

Kun Hoe Chung

Jin Seog Kim

Sung Hun Kim

In Young Choi

Won Hoon Jung

Tae Joon Kim

Dong Ju Jeon

Dae-Whang Kim

Ki Young Kim

Myung-Ae Bae

Jun Hyuk Choi

Tae Hyun Oh

Suk Jin Koo

Man Seok Jeon

Tae Jun Kim

Jong Su Lim

Nam Gyu Cho

Ki Hwan Hwang

Dong Guk Lee

Mee Young Seok

Tae-Joon Kim

Kyung Sung Kim

Bong Jin Chung

Young Kwon Kim

Sang Soon Park

Dae-Seop Shin

Kyu Seok Hwang

Jung Yoon Yang

Byung Hoi Lee

Seong Soon Kim

The present invention relates to a novel isoquinoline derivative, a preparing method thereof, and a pharmaceutical composition for preventing or treating autophagy related diseases containing the same as an active ingredient. The novel isoquinoline furanone derivative according to the present invention is capable of regulating autophagy activity, and thus, by using this derivative as an active ingredient, there is a useful effect that can be used as a pharmaceutical composition for preventing or treating autophagy-related diseases such as neurodegenerative diseases, cancer, metabolic diseases, inflammatory diseases or melanogenesis-related diseases, a health functional food composition for ameliorating thereof, or a cosmetic composition with a whitening function.

Isoquinoline derivative, preparing method thereof, and pharmaceutical composition for preventing or treating autophagy related diseases containing the same as an active ingredient

Provided is an industrial method for the preparation of [5-{(2,6-difluorobenzyloxy)methyl}-4,5-dihydro-5-methyl-3-(3-methylthiophene-2-yl)-isoxazole](common name: methiozolin) represented by Formula 1 that is a herbicidal substance in high-purity.

Industrial method for the preparation of high-purity methiozolin

Disclosed are uracil compounds represented by Formula 1, a method for preparing the compounds, and a herbicide including the same as an active ingredient: 

Uracil compounds and a herbicide comprising the same

The present invention relates to a preparing method of 2-phenylalkanoic acid derivatives and more particluarly, to the preparing method of 2-phenylalkanoic acid derivatives expressed by formula (1) from 5,6-dihydro-2(4H)-benzofuranone as a starting material in the presence of a catalyst, organic acid alkali metal salt, in a mild condition, wherein R prepresents benzoyl, naphthoyl, nicotinoyl, furoyl or thenoyl group; and R prepresents a hydrogen atom or C -C alkyl group.

Preparing method of 2-phenylalkanoic acid derivatives

Herbicidal phenoxypropionic acid N-alkyl-N-2-fluorophenyl amide compounds

Highly selective herbicidal phenoxypropionic acid alkoxycarbonyl anilid compounds and method of preparing the same

A process for preparing an o-(carboalkoxy)phenylmethanesulfonyl chloride derivative of formula (1),

Process for preparing o-(carboalkoxy)phenylmethanesulfonyl chloride derivatives

Thiophenesulfonylurea derivatives

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Daejeon, South Korea

Jae Chun Woo