Ajou University Industry-Academic Cooperation Foundation

Other

Standigm Inc

Jae Bong Kim

Sang Myun Park

Yu Ree Choi

Hee Jung Koo

Jin Han Kim

So Jeong Yun

Soo Jeong Kim

Min Young So

Sang Ok Song

Soo Jin Park

A composition for preventing or treating synucleinopathies, which includes efavirenz or a salt or solvate thereof and a pharmaceutically acceptable carrier, is provided. The composition is useful in preventing or treating synucleinopathies, such as Parkinson's disease, dementia with Lewy bodies, and multiple system atrophy, because the composition serves to hinder cell-to-cell transmission of alpha-synuclein, prevent intracellular aggregation of α-synuclein, and inhibit transmission of aggregated α-synuclein.

Composition for treating synucleinopathies

A composition including a substance that inhibits an expression or activity of c-src and its use in inhibiting aggregation and/or migration of α-syn are disclosed. The composition may be a pharmaceutical composition and can be used for preventing or treating synucleinopathy. The substance can inhibit the signal transduction induced by α-syn migrating to adjacent cells, thus mitigating the cytotoxic influence of α-syn on the adjacent cells; and can inhibit the denaturation of monomeric α-syn into aggregated α-syn, which may be a major cause of synucleinopathy, and thus, can be beneficially used as a therapeutic agent for synucleinopathy.

Pharmaceutical composition comprising expression or activity inhibitor of c-src for preventing or treating synucleinopathy

The present invention relates to a pressure-sensitive sheet having a function which can permanently conserve an indication showing different concentrations according to the intensity of an external pressure applied to pressure-sensitive paper. The pressure-sensitive sheet proposed by the present invention comprises a set of: a pressure-sensitive paper () having a surface to which ink () is applied; and a transparent film () which is disposed on the pressure-sensitive paper () and has a rear surface to which an adhesive agent () is applied.

Pressure-sensitive sheet

Growing community of inventors

Busan, South Korea

Jae Bong Kim