Emd Millipore Corporation

Jad Jaber

Wilson Moya

Mikhail Kozlov

Neil P Soice

John Charkoudian

James Hamzik

Nripen Singh

Yu Zhang

Arezki Boudif

Matthew T Stone

Ajish Potty

Michael W Phillips

William Cataldo

Christopher Gillespie

Alex Xenopoulos

Michael Phillips

The embodiments described herein relate to agarose ultrafiltration membrane composites and methods for making and using the same.

Agarose ultrafiltration membrane composites for size based separations

The present invention relates to improved processes and systems for purification of biological molecules, where the processes can be performed in a continuous manner.

Purification of biological molecules

The present invention relates to a selectively soluble polymer capable of binding to a desired molecules in an unclarified mixture containing various biological materials and the methods of using such a polymer to purify a molecule from such a mixture. The polymer is soluble in the mixture under a certain set of process conditions such as pH or temperature and/or salt concentration and is rendered insoluble and precipitates out of solution upon a change in the process conditions. The polymer is capable of binding to the desired molecule (protein, polypeptide, etc) and remains capable of binding to that molecule even after the polymer is precipitated out of solution. The precipitate can then be filtered out from the remainder of the stream and the desired biomolecule is recovered such as by elution and further processed.

Purification of proteins

The present invention provides novel and improved stimulus responsive polymers and methods of using the same for the purification of biomolecules.

Stimulus responsive polymers for the purification of biomolecules

The present invention relates to a selectively soluble polymer capable of binding to a desired biomolecules in a mixture containing various biological materials and the methods of using such a polymer to purify a biomolecule from such a mixture. The polymer is soluble in the mixture under a certain set of process conditions such as pH or temperature and/or salt concentration and is rendered insoluble and precipitates out of solution upon a change in the process conditions. The polymer is capable of binding to the desired biomolecule (protein, polypeptide, etc) and remains capable of binding to that biomolecule even after the polymer is precipitated out of solution. The precipitate can then be filtered out from the remainder of the stream and the desired biomolecule is recovered such as by elution and further processed.

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Sudbury, MA, United States of America

Jad Jaber