Merck Frosst Canada, Inc.

Merck + Co., Inc.

Jacques Yves Gauthier

Christophe Mellon

Chun Sing Li

Jacques-Yves Gauthier

Robert N Young

Robert J Zamboni

Michel L Belley

Daniel Guay

Richard Frenette

Cheuk K Lau

Yves Leblanc

Michel Therien

Rejean Fortin

Thomas R Verhoeven

John W Gillard

Cameron Black

Yves Ducharme

Pierre A Hamel

Patrick Roy

Masatoshi Kakushima

Douglas K Miller

Jillian F Evans

Yvan Guinon

Richard A Dixon

The invention encompasses the novel compound of Formula I useful in the treatment of cyclooxygenase-2 mediated diseases. ##STR1## The invention also encompasses certain pharmaceutical compositions for treatment of cyclooxygenase-2 mediated diseases comprising compounds of Formula I.

N-benzyl indol-3-yl butanoic acid derivatives as cyclooxygenase

Compounds having the formula I: ##STR1## are antagonists of the actions of leukotrienes. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents. They are also useful in treating angina, cerebral spasm, glomerular nephritis, hepatitis, endotoxemia, uveitis, and allograft rejection.

Pyridine-substituted benzyl alcohols as leukotriene antagonists

Compounds having the formula: ##STR1## are leukotriene antagonists and inhibitors of leukotriene biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory, and cytoprotective agents.

Hetaryl styryl quinolines as leukotriene inhibitors

An 18kD protein (FLAP) has been isolated from rat and human cells which is necessary for production of leukotrienes from arachidonic acid in mammalian cells containing 5-lipoxygenase. The gene (cDNA) encoding for FLAP has also been produced.

5-lipoxygenase activating protein

Thioacids, thiols, an acid, and an aldehyde are used to produce chiral thioacetals of the general formula. ##STR1## The compounds are leukotriene antagonists.

Synthesis of chiral thioacetals and thioethers

Diarylstrylquinoline diacids and pharmaceutical compositions thereof

Compounds having the formula: ##STR1## are antagonists of leukotrienes of C.sub.4, D.sub.4 and E.sub.4, the slow reacting substance of anaphylaxis, and inhibitors of their biosynthesis. These compounds are useful as anti-asthmatic, anti-allergic, anti-inflammatory agents, anti-psoriatic agents, and cytoprotective agents.

Leukotriene antagonists, compositions and methods of use thereof

The present invention relates to a stereo-selective synthesis of leukotriene antagonists. More particularly, this invention relates to the stereo-selective synthesis of (.beta.S,.gamma.R) and (.beta.R,.gamma.S)-4-((3-(4-acetyl-3-hydroxy-2-propyl(phenoxy)propyl)-thio -.gamma.-hydroxy-.beta.-methylbenzenebutanoic acid, and related compounds. These compounds are useful therapeutic agents for treating allergic conditions, asthma, cardiovascular, disorders, inflammation and pain in mammals, especially humans. The compounds are also useful for inducing cytoprotection in mammals, especially humans.

Stereoselective synthesis of leukotriene antagonists

Growing community of inventors

Laval, Canada

Jacques-Yves Gauthier