Dr. Karl Thomae Gmbh

Karl Thomae Gmbh

Jacques Van Meel

Norbert Hauel

Michael Entzeroth

Wolfgang Wienen

Berthold Narr

Uwe Joerg Ries

Andreas Bomhard

Willi Diederen

Joachim Heider

Klaus Reinhold Noll

Armin Heckel

Volkhard Austel

Manfred Reiffen

Wolfgang Grell

Rainer Zimmermann

Manfred Psiorz

Annerose Mauz

Andres Bomhard

The invention relates to benzimidazoles of the formula ##STR1## in which R.sub.1 to R.sub.4 are as defined in claim 1,

Benzimidazoles, medicaments containing these compounds and processes for

The invention relates to benzimidazoles of general formula ##STR1## wherein R.sub.1 to R.sub.4 are as defined herein, the 1-, 3-isomer mixtures thereof and the addition salts thereof. The new compounds are useful, in particular, as angiotensin antagonists.

Benzimidazoles, pharmaceutical compositions containing these compounds

The invention relates to benzimidazoles of the formula ##STR1## in which R.sub.1 to R.sub.2 are as defined in claim 1, 1 and 3 isomer mixtures thereof and addition salts thereof which have valuable properties. In particular, the novel compounds are angiotensin II antagonists.

Benzimidazoles and medicaments containing these compounds

The invention relates to benzimidazoles of general formula ##STR1## Exemplary compounds are: (a) 4'-[[2-Ethyl-4-methyl-6-[(2-dimethylamino-3,4-dioxo-1-cyclobuten-1-yl)amin o]-1H-benzimidazol-1-yl]-methyl]-2-(1H-tetrazol-5-yl)-biphenyl,

A phenylalkyl derivative of the formula ##STR1## wherein R.sub.a to R.sub.f, A and B are substituents and n is the number 0 or 1. These phenylalkyl derivatives possess angiotensin antagonist activity.

Phenylalkyl derivatives, with pharmaceutical activity

The invention relates to substituted benzimidazolyl derivatives of the general formula ##STR1## wherein A and R.sub.a to R.sub.c are defined as in claim 1, the mixtures of position isomers thereof and the salts thereof which have valuable properties. These compounds have valuable pharmacological properties, particularly angiotensin-antagonistic effects and preferably angiotensin-II-antagonistic effects.

Substituted benzimidazolyl derivatives and pharmaceutical compositions

Imidazo[1,2-a]pyridines of the formula ##STR1## wherein R.sub.a to R.sub.e are as defined herein, the enantiomers and the salts thereof, which are useful as angiotensin antagonists and for treating conditions treatable with angiotensin antagonists.

Imidazo[1,2-a]pyridines, pharmaceutical compositions containing these

The invention relates to new 2-hydroxy-n-propylamines of the formula

2-hydroxypropylamino-alkyl-benzimidazoly-5-yl derivatives and their use

The invention relates to new imidazo-benzoxazinones of formula ##STR1## wherein the substituents are defined herein below, which compounds are useful in the treatment of cardiovascular disorders.

Imidazo-benzoxazinones, the preparation thereof and pharmaceutical

The invention relates to new imidazo derivatives of the formula ##STR1## wherein 'A-D and R.sup.1 -R.sup.3 are as defined in the specification'. The new compounds have valuable pharmacological properties, particularly antithrombotic and cardiovascular properties such as a cardiotonic activity and/or an effect on blood pressure, and can be prepared using methods known per se.

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Mittelbiberach, Germany

Jacques Van Meel