Ucb S.a.

Jacques Timmermans

Michel Deleers

Domenico Fanara

Monique Berwaer

Guy Bodson

Charles Dogimont

The present invention relates to new pseudopolymorphic forms of 2-&lsqb;2-&lsqb;4-&lsqb;bis (4-fluorophenyl)methyl&rsqb;-1-piperazinyl&rsqb;ethoxy&rsqb;acetic acid dihydrochloride, namely, anhydrous 2-&lsqb;2-&lsqb;4-&lsqb;bis(4-fluorophenyl)methyl&rsqb;-1-piperazinyl&rsqb;ethoxy&rsqb;acetic acid dihydrochloride and 2-&lsqb;2-&lsqb;4-&lsqb;bis(4-fluorophenyl)methyl&rsqb;-1-piperazinyl&rsqb;ethoxy&rsqb;acetic acid dihydrochloride monohydrate. It also relates to processes for the preparation of these pseudopolymorphic forms and to pharmaceutical compositions containing them.

Pseudopolymorphic forms of 2-&lsqb;2-&lsqb;4-&lsqb;Bis (4-fluorophenyl) methyl&rsqb;-1-piperazinyl&rsqb;ethoxy&rsqb;acetic acid dihydrochloride

The present invention relates to new pseudopolymorphic forms of 2-&lsqb;2-&lsqb;4-&lsqb;bis(4-fluorophenyl)methyl&rsqb;-1-piperazinyl&rsqb;ethoxy&rsqb;acetic acid dihydrochloride, namely, anhydrous 2-&lsqb;2-&lsqb;4-&lsqb;bis(4-fluorophenyl)methyl&rsqb;-1-piperazinyl&rsqb;ethoxy&rsqb;acetic acid dihydrochloride and 2-&lsqb;2-&lsqb;-bis(4-fluorophenyl)methyl&rsqb;-1-piperazinyl&rsqb;ethoxy&rsqb;acetic acid dihydrochloride monohydrate. It also relates to processes for the preparation of these pseudopolymorphic forms and to pharmaceutical compositions containing them.

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Virginal, Belgium

Jacques Timmermans