Université Grenoble Alpes

Centre Hospitalier Universitaire Grenoble

Centre National De La Recherche Scientifique

Centre Hospitalier Universitaire Grenoble Alpes

Jacques Thelu

Philippe Cinquin

Donald Keith Martin

Jean-Pierre Alcaraz

Abdelkader Zebda

Denis Favier

Bertrand Toussaint

Audrey Le Gouellec

Aziz Bakri

Sarra El Ichi

Patrick Tuvignon

Dominique Schneider

Thierry Alonso

Nawel Khalef

Thomas Soranzo

Sylvain Besson

Jean-Marc Kweter

Fabian Reche

Max Maurin

Sarra El Ichi Ribault

The application relates to a device for collecting a sample of intestinal fluid comprising a polymeric inner material having an at least partially compressed open cell structure, having a volume Vand being suitable for swelling to a volume greater than or equal to 1.1×Vby absorbing intestinal fluid, said material being encased with an elastic polymeric casing impervious to digestive fluid, said casing comprising at least one opening allowing the intake of intestinal fluid into the inner material, a gastro-resistant material suitable for dissolving in intestinal fluid at 37° C. being disposed on top of each opening, and at least one mechanism for closing the opening(s).

Device for collecting intestinal fluid

A capsule configured for collecting samples in the intestine, comprising a body delimiting at least one compartment for receiving samples and comprising at least one opening for samples intake, and a mobile mechanism for opening and/or closing the opening controlled by the dissolution of a material which is dissolvable in the intestine.

Device for taking an intestinal sample

The device, that can be implanted in the intestinal cavity, comprises a reactor comprising a semi-permeable or porous membrane or coating linked to a element for attachment to an intestinal or gastric wall. The reactor can be in the form of a ribbon, a structure having more than two faces or an open structure delimiting a lumen, comprising, or formed from, a semi-permeable or porous membrane. The reactor can also delimit, at least partially with the semi-permeable or porous membrane of same, a closed inner space. The reactor can comprise or carry enzymes or micro-organisms, in particular bacteria or yeast. The reactor is used for generating a chemical reaction with one or more molecules present in the intestine, or for producing one or more biologically active molecules. It can, in particular, be used for consuming sugars, disaccharides and simple sugars or producing essential amino acids or other molecules having a positive effect on the health.

Implantable intestinal reactor

Growing community of inventors

Crolles, France

Jacques Thelu