Medtronic Corevalve LLC

Other

Medtronic, Inc.

Evalve, Inc.

Medtronic Cv Luxembourg S.a.r.l.

Biosensors International Group, Ltd.

Vapomed Limited

Corevalve, S.a.

Recor Medical, Inc.

Devax, Inc.

Corevalve, Inc.

Seguin, Jacques

Laborde, Jean-claude

Jacques Seguin

Georg Börtlein

Jean-Claude Laborde

Than Nguyen

Robert John Elicker

Bruno Lecointe

Emad Sabry

Eugene J Jung

Reinhard J Warnking

Hung Nguyen

Stan Komatsu

Georg Boertlein

Yong Zou

Edward Pannek

Mano Iyer

Robert Rogier

Systems and methods are provided involving various medical monitoring and/or diagnostic systems. The monitoring and diagnostic systems may involve one or more connected devices (e.g., a smart watch and/or other sensor device) and may continuously monitor an individual and analyze physiological and other data to determine a medical device, condition or event has occurred. The monitoring and diagnostic systems may be a guided self-examination system for determining a medical diagnosis, condition or event. The medical monitoring and diagnostic systems may even be specific to a family or individuals in a certain geographic location.

Systems and methods for automated medical monitoring and/or diagnosis

An intervalvular implant for a mitral valve having a frame and a membrane covering the frame is provided. The frame includes an elongated base portion formed by two curved or chevron branches connected to two connection areas of the implant for connecting to the annulus of the mitral valve. The frame further includes a longitudinal hoop extending in a plane substantially perpendicular to the plane in which the elongated base portion extends. The membrane is flexible and extends from one branch to the other branch while passing around the longitudinal hoop. The membrane may be connected to the branches without being stretched between the branches and the hoop so that the membrane forms lateral portions on each side of the implant that are able to transition between an outwardly convex, concave shape, and an outwardly concave, recessed shape.

Intervalvular implant for a mitral valve

Devices and methods for sequential aerosolized administration of pharmaceutical agents. A portable device may be used to administer an initial dose of an active formulation comprising at least one first pharmaceutical agent and a subsequent dose of an active formulation comprising at least one second pharmaceutical agent that may have the effect of countering, enhancing, or mitigating the first pharmaceutical agent.

Dual chamber inhaler for sequentially administering multiple drugs

The invention relates to a system for the sequential intranasal administration of at least one active ingredient selected from a DR group having at least one side effect of respiratory depression and at least one active ingredient selected from an ADR group that counteracts the respiratory depression that may be induced by the active ingredients of the DR group. The invention also relates to a portable sequential intranasal administration device comprising an intranasal administration system according to the principles of the invention.

Pharmaceutical composition and device for treating pain

A prosthetic valve assembly for use in replacing a deficient native valve comprises a replacement valve supported on an expandable valve support. If desired, one or more anchor may be used. The valve support, which entirely supports the valve annulus, valve leaflets, and valve commissure points, is configured to be collapsible for transluminal delivery and expandable to contact the anatomical annulus of the native valve when the assembly is properly positioned. The anchor engages the lumen wall when expanded and prevents substantial migration of the valve assembly when positioned in place. The prosthetic valve assembly is compressible about a catheter, and restrained from expanding by an outer sheath. The catheter may be inserted inside a lumen within the body, such as the femoral artery, and delivered to a desired location, such as the heart. When the outer sheath is retracted, the prosthetic valve assembly expands to an expanded position such that the valve and valve support expand within the deficient native valve, and the anchor engages the lumen wall.

Prosthetic valve for transluminal delivery

A prosthetic heart valve comprises a collapsible and expandable support frame comprising a longitudinal axis. The frame comprises a first circumferential undulating structure defining an outflow end of the frame, and a second circumferential undulating structure spaced apart from the first circumferential undulating structure. The frame also comprises a plurality of struts longitudinally aligned with the longitudinal axis of the frame, and connecting the first circumferential undulating structure to the second circumferential undulating structure. Each strut of the plurality of struts comprises a first end terminating at a trough of the first circumferential undulating structure, and a second end terminating at a peak of the second circumferential undulating structure. The prosthetic heat valve also comprises a biological tissue valve coupled to the frame. The prosthetic heart valve is configured to be collapsed for introduction into a patient using a catheter and to be expanded for deployment at an implantation site.

Transcatheter heart valves

Apparatus and methods for repairing a cardiac valve, e.g., a mitral valve, are provided. The apparatus may include an expandable frame defining a curved structure in the expanded deployed state and a membrane coupled to the expandable frame. The membrane may curve around a native leaflet, e.g., the posterior leaflet, in a first plane and curve around another leaflet, e.g., the anterior leaflet, in an orthogonal plane. The membrane may be adapted to be suspended in the flow path of the cardiac valve such a first surface of the membrane abuts the native leaflet during systole and a second surface of the membrane abuts the other native leaflet during systole, thereby reducing cardiac valve regurgitation.

Apparatus and methods for treating cardiac valve regurgitation

Implants formed by a helically wound wire and methods of using same for the treatment of a mitral heart valve. According to the invention, it has dimensions such that it is able to be screwed into the wall of the annulus and/or into the cardiac wall adjoining the annulus such that a portion of the annulus and/or of the wall is located in the perimeter of the implant; and it comprises at least one first coil able, during said screwing of the implant, to insert itself into the wall while having a first dimension and at least one second coil having a second dimension, or adopting this second dimension after implantation, the second dimension being smaller than the first dimension such that the implant, once inserted, enables contraction of the wall portion located in the perimeter of the implant.

Implant for treatment of a heart valve, in particular a mitral valve, material including such an implant, and material for insertion thereof

Provided is a surgical instrument including an external tube () and two elongated members () positioned in the tube (), each of which includes a distal end () for capturing one of the two tissue zones (M, M) to be attached. The instrument () may further include a catching member () for each tissue (M, M) to be attached; a rod () linked to each catching member () enabling tension to move axially, the rod () being separable from said catching member () when a tension is exerted on it beyond a certain threshold; and a member () forming a stop for locking axially each catching member () during the tensioning.

Surgical device for connecting soft tissue

Methods for delivering a prosthetic heart valve include advancing a delivery catheter containing the prosthetic heart valve to a deployment native heart valve, advancing an inner core movably coupled to a restraining sheath of the delivery catheter to expose a first end of the prosthetic heart valve, and advancing the inner core and the restraining to expose a second end of the prosthetic heart valve. The delivery catheter can include a distal flange located at a distal end of an outer core of the catheter body, configured to restrict distal longitudinal displacement of the prosthetic heart valve, and a retaining structure located proximally from the distal flange along the outer core of the catheter body, configured to restrict proximal longitudinal displacement of the prosthetic heart valve.

Methods for delivering a self-expanding valve

This implant () is formed by a helically wound wire (). According to the invention, it has dimensions such that it is able to be screwed into the wall of the annulus () and/or into the cardiac wall () adjoining this annulus () such that a portion of said annulus () and/or of said wall () is located in the perimeter of the implant (); and it comprises at least one first coil able, during said screwing of the implant (), to insert itself into said wall while having a first dimension and at least one second coil having a second dimension, or adopting this second dimension after implantation, said second dimension being smaller than the first dimension such that the implant (), once inserted, enables contraction of said wall portion located in the perimeter of this implant ().

This material comprises an annuloplasty member () able to be introduced using a catheter () through minimally invasive vascular access, then to be delivered by said catheter and fixed to the valve annulus (). According to the invention, it includes at least one catheter () comprising: &#x2014;at least one guide member () able to be deployed from said catheter () such that it extends along one portion of the valve annulus () of the valve (), in the immediate proximity of said valve annulus, and &#x2014;an implant () having a helical shape engaged on said guide member (), connected, with separation possibility, to actuation means () making it possible to cause this implant () to move forward while driving it in rotation around its axis; the implant () can thus be deployed from the catheter () while being simultaneously moved forward and driven in rotation along its axis, said rotation enabling the implant () to penetrate the tissue of the valve annulus () while being guided along said annulus by said guide member ().

Material for treatment of a heart valve, in particular a mitral valve

A prosthetic heart valve comprises a biological tissue valve and a collapsible and expandable support frame having a longitudinal axis. The frame comprises an outflow circumferential structure defining an outflow end of the frame and consisting essentially of a single row of diamond-shaded expandable cells. The frame also comprises three V-shaped structures spaced apart from the outflow circumferential structure and three struts longitudinally aligned with the longitudinal axis of the frame. The three struts are configured to facilitate mounting the biological tissue valve to the frame and interconnect the outflow circumferential structure to the three V-shaped structures. The frame also includes three undulating structures, each of the three undulating structures interconnecting respective adjacent V-shaped structures of the three V-shaped structures. The prosthetic heart valve is configured to be collapsed for introduction into a patient using a catheter and to be expanded for deployment at an implantation site.

Growing community of inventors

Old Windsor, United Kingdom

Jacques Seguin