Lars- Laboratoire D'application Et De Recherche Scientifique

Jacques-Philippe Laboureau

Veronique Migonney

Bernard Brulez

Mihaela Ciobanu

Graciela Pavon-Djavid

Alain Siove

Gérard Berbey

Biomimetic artificial prostheses which are made from polyester, such as polyethylene terephthalate, and a method for the biomimetic functionalization of such prostheses. The method includes a step involving the grafting of biologically-active polymers or copolymers to the polyester surface of the prostheses, the grafting step consisting of the peroxidation of the surface by ozonation followed by a step including the radical polymerization of a solution of at least one monomer. The method also includes an optional step consisting in impregnating the prostheses with type I and/or II collagen and/or fibronectins. The prostheses thus obtained enable a normal and uniform regrowth of the fibroblasts, thereby significantly improving the biological integration of such polyester prostheses.

Biomimetic prosthetic ligament and production method thereof

Method for production of a prosthetic ligament (), for the replacement of a natural joint ligament, having a global cylindrical form and including a medial intra-articular section () between two intra-osseous end parts (). The method includes a step of the rolling or folding on itself of a web of synthetic polymer fibers, followed by a step of installation of a traction thread () to each of the ends () of the ligament (), then a step of placing a tip () on the ends (), characterized in that the placing of the tip () includes producing a radial ligature () of the ligament () provided with the traction threads (), by of a ligature thread ().

Method for fixing traction threads to ends of a prosthetic ligament

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Le Tignet, France

Jacques-Philippe Laboureau