Oravax, Inc.

Natural Environment Research Council

Oravax-merieux Co.

Jacques Pappo

Thomas P Monath

Farshad Guirakhoo

Harold Kleanthous

Samuel K Ackerman

Cynthia K Lee

Richard A Weltzin

Polly Roy

Hitesh Bhagat

Gopalan Soman

William D Thomas

Richard D Nichols, Jr

Thomas H Ermak

Ilene Sussman

Thomas Ermak

Methods and compositions are provided for prophylactic and antibacterial therapy for Helicobacter, particularly for Helicobacter pylori, infection of humans. The immunogenic composition of the invention is composed of a plurality of multimeric complexes, each complex being composed of recombinant, enzymatically inactive Helicobacter pylori urease. Each multimeric complex is composed of six Urease A subunits and six Urease B subunits. Alternatively, the composition is composed of a mixture of multimeric complexes, wherein each multimeric complex in the mixture is composed of six Urease A subunits and six Urease B subunits or four Urease A subunits and four Urease B subunits.

Multimeric, recombinant urease vaccine

Method of inducing a mucosal and or/systemic immune response in a host, comprising the step of administering to the host an effective amount of a Bluetongue antigen in the form of virus like and/or virus core like particles. Vaccines are also provided.

Oral immunization with multiple particulate antigen delivery system

Growing community of inventors

Cambridge, MA, United States of America

Jacques Pappo