Synthelabo

Jacques Menin

Dennis C Bigg

Pascal George

Mireille Sevrin

Christian Maloizel

Daniel C Obitz

Claude C Morel

Jean-Pierre Merly

Juan Antonio Diaz Martin

Maria Dolores Jimenez Bargueno

Michel Peynot

Corinne Veronique

Jean Pierre Merly

Ulpiano Martin Escudero Perez

Manuel Bedoya Zurita

Gregorio Del Sol Moreno

Magali Romanach Ferrer

Denis Bigg

Pyrrole derivatives of formula: ##STR1## in which R.sub.1 represents a hydrogen or halogen atom, a linear or branched C.sub.1-6 alkyl group, a C.sub.3-6 alkenyl group, a C.sub.1-4 alkoxymethyl group, benzyl, a phenyl group optionally substituted by one or more halogen atoms or alkyl radicals, a CO.sub.2 R group in which R represents a linear or branched C.sub.1-4 alkyl radical, phenyl or benzyl, or a CONR'R' group in which R' and R' each represent, independently of one another, a hydrogen atom or a linear or branched C.sub.1-4 alkyl radical,

4H-thieno[3,4-c]pyrrole derivatives

[(1-Arylpyrrolidin-2-yl)methyl]piperazine compounds corresponding to the formula ##STR1## in which Z denotes a group of formula N-R.sub.1 in which R.sub.1 is either a hydrogen atom or a C.sub.1-3 alkyl group or a group of formula Ar--C.sub.n H.sub.2n in which n denotes 0, 1 or 2 and Ar denotes a phenyl group optionally substituted by one or more halogen atoms and/or C.sub.1-3 alkyl or C.sub.1-3 alkoxy radicals, or a group of formula COR.sub.2 in which R.sub.2 denotes the CH.sub.3, C.sub.6 H.sub.5, CH.sub.2 C.sub.6 H.sub.5 or OC.sub.2 H.sub.5 group and their salts of addition to pharmaceutically acceptable acids. The compounds are useful for the treatment of neurological disorders.

[(1-arylpyrrolidin-2-yl)methyl]piperazine derivatives, their preparation

A compound which is a pyrido[3,4-b]derivative of formula (I) ##STR1## in which R is a hydrogen atom or an alkyl carbonyl, arylalkylcarbonyl or arylcarbonyl group of formula COR.sub.1 wherein R.sub.1 is a C.sub.1 -C.sub.6 alkyl group, a benzyl group or a phenyl group unsubstituted or substituted with 1 to 3 substituents chosen from halogen atoms and trifluoromethyl, C.sub.1 -C.sub.3 alkyl and C.sub.1 -C.sub.3 alkoxy groups or R is an alkoxycarbonyl or benzyloxycarbonyl group of formula COOR.sub.2 wherein R.sub.2 is a C.sub.1 -C.sub.6 alkyl group or a benzyl group, or R is a substituted aminocarbonyl group of formula CONHR.sub.3 wherein R.sub.3 is a C.sub.1 -C.sub.6 alkyl group or a phenyl group, or R is an arylsulphonyl group of formula SO.sub.2 R.sub.4 wherein R.sub.4 is a phenyl group, or a pharmacologically acceptable acid addition salt thereof useful for treating hypertension, depressive state or anxiety state.

2-[(4-piperidyl)methyl]-1,2,3,4-tetrahydro-9H-pyrido[3,4-b]indole

Derivatives of formula (I) ##STR1## in which X denotes a hydrogen or halogen atom, an alkoxy radical, an alkyl radical or an allyloxy radical, and R denotes a linear or branched alkyl radical, a cycloalkylalkyl radical, an alkenyl radical, an arylalkyl radical which can bear one or more substituents chosen from halogen atoms and methyl, methoxy and methylenedioxy radicals, or alternatively an optionally substituted phenyl radical, as well as the addition salts thereof with pharmaceutically acceptable acids produce an .alpha..sub.2 -receptor antagonist effect.

2-(4,5-Dihydro-1H-imidazol-2-yl)-2,3-dihydroindole derivatives and their

Compounds of the general formula (I) ##STR1## in which R.sub.1 is a hydrogen atom or a (C.sub.1 -C.sub.4)-alkyl, benzyl, phenethyl or methoxy group and R.sub.2 is a hydrogen atom or a methyl group, and their addition salts with pharmaceutically acceptable acids are useful, as such or in pharmaceutical compositions containing them in association with excipients, as .alpha..sub.2 -antagonists.

2-(Inden-2-yl)-imidazoline derivatives, process for their preparation

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Vitry Sur Seine, France

Jacques Menin