Amgen Inc.

Johnson Matthey Public Limited Company

Jacques Lepaih

Steven Mennen

Amin Bornadel

Serena Bisagni

Ahir Pushpanath

Iustina Slabu

Simon J Hedley

Jason S Tedrow

Beatriz Dominguez

Jason Tedrow

Simon Hedley

A method for reducing a substrate selected from 2-methyl-5-nitropyridine and methyl 4-(2-fluoro-3-nitrobenzyl)piperazine-1-carboxylate is provided catalysed by a nitroreductase and a disproportionation agent.

Method of reducing aromatic nitro compounds

Disclosed herein is a method of reducing an aromatic nitro compound. In some embodiments the method comprises the step of contacting an aromatic nitro compound with a catalyst, wherein, the catalyst comprises, a disproportionation agent, and a biocatalyst. Also disclosed is a biocatalyst for use in the method, use of a disproportionation agent, and a biocatalyst, as a catalyst for reducing an aromatic nitro compound, and a kit comprising a disproportionation agent, and a biocatalyst.

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Cambridge, United Kingdom

Jacques Lepaih