Ipsen Pharma S.a.s.

Societe De Conseils De Recherches Et D'applications Scientifiques (s.c.r.a.s.)

Ipsen Pharma

Jacques Lannoy

Dennis Bigg

Pierre-Etienne Chabrier De Lassauniere

Christophe Thurieau

Jacques Pommier

Jeremiah Harnett

Anne-Marie Liberatore

Zheng Xin Dong

Pierre Etienne Chabrier De Lassauniere

Jermiah Harnett

Ann-Marie Liberatore

Anne Marie Liberatore

The invention relates to thiazole, oxazole, imidazole, isoxazole and isoxazoline derivatives of general formula (I) wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is notably selected from various optionally substituted aromatic radicals, B is notably hydrogen, alkyl or phenyl, Rand Rare notably independently hydrogen, alkyl or cycloalkyl and &#x3a9; is &#x2014;NRRor &#x2014;OR, Rand Rare notably independently hydrogen, alkyl, cycloalkyl or &#x2014;(CH)&#x2014;COOR, Ris notably alkyl or haloalkyl and Ris notably hydrogen or alkyl. These compounds have advantageous pharmacological properties which allow their use in therapeutics, notably for treating neurodegenerative disorders or pain.

Derivatives of heterocycles with 5 members, their preparation and their use as medicaments

Thiaxozle, oxazole, imidazole, isoxazole and isoxazoline compounds of the formula wherein Het is thiazole, oxazole, imidazole, isoxazole or isoxazoline, n is an integer from 0 to 6, A is selected from the various optionally substituted aromatic radicals defined in the specification, B is hydrogen, alkyl or phenyl, Rand Rare independently hydrogen, alkyl or cycloalkyl or Rand Rtaken together with the carbon atom which carries them, form a carbocycle with 3 to 7 members and &#x3a9; is &#x2014;NHRor &#x2014;OR, Rand Rare independently hydrogen, alkyl, cycloalkyl or &#x2014;(CH)COOR, Ris alkyl or haloalkyl and Ris hydrogen or alkyl having advantageous pharmacological properties which allow their use in therapeutics, for treating neurodegenerative disorders or pain.

Growing community of inventors

Bievres, France

Jacques Lannoy