The University of Mississippi

L'université Catholique De Louvain

Jacques Henri Poupaert

Rae Matsumoto

Christopher R McCurdy

Christophe Mesangeau

Sanju Narayanan

Bonnie Ann Avery

Ahmed Hassan Amin Abdelazeem

A compound useful for treating subjects in need of therapy involving sigma receptors or for alleviation of affects resulting from drug abuse having the general formula I in which Rcan be a radical of an optionally substituted C-4 to C-7 N-containing heterocycle such as, for example, radicals of optionally substituted piperidines, optionally substituted piperazines, optionally substituted tetrahydropyridines, optionally substituted azepanes, tertiary amines (cyclic or acyclic), isoindoline-1,3-dione, or optionally substituted tetrahydroisoquinolones (aromatically substituted): Rcan each independently be any one or combinations of the following moieties, cyano, nitro, acyl, alkyl, amido, azido, isothiocyanate, isocyanate optionally substituted anilino, halogens, ethers, sulfonamides, thioacyl, nitro, aromatic, heterocyclic, olefinic, acetylene, deuterium, or tritium; Y can be either CH, CH, O, S, OCH, N&#x2014;R, N&#x2014;Ar, C&#x2014;R, C&#x2014;Ar; Z can be either H, O, S, S&#x2014;R or NR. R groups can be either H, aryls, alkyls, or cycloalkyls; 'n' can be 1 to 5 carbons in length and stereoisomers, functional analogs, and pharmaceutically acceptable salts thereof and wherein the moiety bridging Rand N can be optionally substituted alkylene, optionally substituted alkenylene or optionally substituted alkynylene and where the alkylene group can include an inserted C-Ccycloalkyl group, aromatic and heterocyclic group.

Highly selective sigma receptor ligands

Compounds having the general formula II, III, or IV wherein Rcan be a radical of an optionally substituted C-4 to C-7 N-containing heterocycle or a radical of an optionally substituted cyclic or acyclic tertiary amine or isoindoline-1,3-dione: Rcan each independently be any one or combinations of the following moieties, cyano, nitro, acyl, alkyl, amido, azido, isothiocyanate, isocyanate, optionally substituted anilino, halogens, ethers, sulfonamides, thioacyl, nitro, aromatic, heterocyclic, olefinic, acetylene, deuterium, or tritium; Y can be either CH, CH, O, S, OCH, N&#x2014;R, N&#x2014;Ar, C&#x2014;R, C&#x2014;Ar; Z can be either H, O, S, S&#x2014;R or NR. R groups can be either H, aryls, alkyls, or cycloalkyls; 'n' can be 1 to 5 carbons in length and stereoisomers, functional analogs, and pharmaceutically acceptable salts thereof and wherein the moiety bridging Rand N can be a substituted alkylene, optionally substituted alkenylene or optionally substituted alkynylene and where the alkylene group can include an inserted C-Ccycloalkyl group, aromatic, and hetercocyclic group; wherein X' is halogen, or C-Chaloalyl; wherein the Ris a C-Cstraight chain or branched chain alkyl or a C-Cstraight chain or branched chain haloalkyl.

Growing community of inventors

Brussels, Belgium

Jacques Henri Poupaert