Institut Pasteur

Luxembourg Institute of Health (lih)

Universite De Reims Champagne Ardenne (u.r.c.a.)

Jacques H M Cohen

Luc Montagnier

Pierre Charneau

Denise Guetard

François Clavel

Andrew Borman

Caroline Quillent

Jacqueline Donjon De Saint-Martin

Xavier Dervillez

Carole Devaux

The present invention is situated in the field of multimers used for targeted therapies. More particularly, the invention relates to methods for preparing multifunctional heteromultimeric protein complexes with a defined ratio of functional components and to multifunctional heteromultimeric protein complexes for directing complement-dependent cytolysis, optionally comprising a scaffold, which display three or more different functional components present in a defined relative ratio, of which one is a tracking component.

Multifunctional heteromultimeric constructs

An HIV-1 type (or subtype) O retrovirus protein, or a natural or synthetic polypeptide or peptide including at least a part of said protein, which is capable of being recognised by antibodies isolated from a serum resulting from infection by an HIV-1 type O VAU strain or an HIV-1 type (or subtype) O DUR strain.

Nucleotide sequences of HIV-1 type (or subtype) O retrovirus antigens

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Reims, France

Jacques H M Cohen