Alliance Pharmaceutical Corp.

Jacques Greiner

Jean G Riess

Alain Milius

Leila Zarif

Pierre Vierling

Sylvie Gaentzler

Frederic Guillod

Maurice Le Blanc

Brigitte Charpiot

Veronique Sanches

Alexandre Manfredi

Perfluoroalkylated amphiphilic phosphorus compounds, corresponding to the formulae: ##STR1## wherein V is O or S;

Perfluoroalkylated amphiphilic phosphorus compounds: preparation and

Perfluorinated amphiphilic phosphorous compounds: liposomal compositions

The present invention relates to nonterminally iodinated fluorinated compositions. The compositions, including, dispersions, emulsions, microemulsions, and gels are useful for biomedical applications, particularly radiography and scintigraphy. The compounds used in the invention preferably have the following general formula:

Iodine-containing fluorocarbon contrast agents

Compounds having a polyhydroxylated hydrophilic moiety, a highly fluorinated moiety and a functional junction group linking said moieties together, wherein said hydrophilic moiety is derived from a polyol or an aminopolyol, and wherein said highly fluorinated moiety consists of a fluorocarbon group wherein at lest 50% of the atoms bonded to the carbon skeleton are fluorine atoms, the other atoms bonded to the carbon skeleton being hydrogen, chlorine or bromine atoms, said highly fluorinated moiety containing at least 4 fluorine atoms; as well as the internal ethers and ketals thereof; process for their preparation; and a compositions containing said compounds as surfactants, together with non polar compounds, for use as gas carriers.

Polyhydroxylated and highly fluorinated compounds, their preparation and

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Nice, France

Jacques Greiner