Schering Corporation

Other

Institut National De La Sante Et De La Recherche Medicale

Schering-plough Corporation

Laboratoires Unicet

Jacques F Banchereau

Odile Djossou

Francois Fossiez

Kevin W Moore

Jan E De Vries

Paulo J Vieira

Pierre Golstein

Anne-Catherine Fluckiger

Rene De Waal Malefyt

Christophe Caux

Pierre Garrone

Eric Rouvier

Rene De Malefyt

Serge J Lebecque

Mala Krishna

Helene Cabrillat

Catherine Favre

John Wijdenes

Serge J E Lebecque

Alain Valle

Leopoldo Flores-Romo

Richard Murray

A method is provided for treating tumors, e.g., lymphocytic leukemias, which comprises administering to a mammal an effective amount of interleukin-10.

Treatment of neoplastic disease with interleukin-10

CTLA-8 antigen from a mammal, reagents related thereto including purified proteins, specific antibodies, and nucleic acids encoding said antigen. Methods of using said reagents and diagnostic kits are also provided.

Purified mammalian CTLA-8 antigens and related reagents

Compositions and methods for using CTLA-8 to treat an abnormal physiological condition in an individual. The methods comprise administering a therapeutically effective amount of CTLA-8 alone, or in combination with other therapeutic reagents; or a CTLA-8 antagonist.

Uses of mammalian CTLA-8 and related reagents

A method is provided for generating human dendritic cells in vitro by treating CD34.sup.+ cells with tumor necrosis factor-.alpha. and interleukin-3 or with GM-CSF. The invention also includes cellular compositions of dendritic cells produced by this method. Dendritic cells of the invention can be used widely as components in many diagnostic and therapeutic systems, including improved mixed lymphocyte reactions for assaying tissue rejection, adoptive immunotherapy of cancer, adoptive immunotherapy of HIV and other viral infections, and SCID-hu mice for human antibody production.

In vitro generation of human dendritic cells

Human monoclonal antibodies against human cytokines and methods of

The present invention relates to a monoclonal antibody-and to the hybridoma that produces it-specific for a surface antigen of activated B cells and T cells transformed by the virus HTLV-I. The hybridoma has been deposited with the European Collection of Annimal Cell Cultures (ECACC) under the number 88062301.

Monoclonal antibodies specific for B cells and HTLV-I transformed T cells

Monoclonal antibodies to .gamma.-interferon and hybridomas producing such antibodies are disclosed. The antibodies are preferably of the immunoglobulin subclass IgG.sub.1, .kappa., and do not bind to interferon-.alpha..sub.2.

Monoclonal antibodies to gamma-interferon, hybridomas producing such

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Ecully, France

Jacques F Banchereau