Centre National De La Recherche Scientifique

Consejo Superior De Investigaciones Cientificas

Université Joseph Fourier

University of Seville

Elf Atochem S.a.

Centre National De La Recherche Scientifique-Cnrs

University Joseph Fourier (Grenoble 1)

Jacques Defaye

Carmen Ortiz-Mellet

Jian-Xin Yu

Jacques Kervennal

Sophie Suc

Maria Gomez-Garcia

Kazimierz Chmurski

José Manuel Garcia-Fernandez

Andree Gadelle

Jose Manuel Garcia-Fernandez

Juan M Benito

Marta Gomez-Garcia

Serge Crouzy

Nicolas Evrard

Ho Law

Jose-Manuel Garcia-Fernandez

The invention relates to a compound corresponding to general formula (I) wherein n is a whole number from 1-6, m is a whole number equal to 5, 6 or 7, Ris an OH group, all Rs are identical, Z is an NHX group, X is a hydrogen atom, and R is a hydrogen atom or a bioidentification element, with the proviso that the compound wherein n=1, m=6, Z=NHand R=OH is excluded.

Derivatives of cyclodextrins, process for their preparation and their use in particular for solubilizing pharmacologically active substances

The invention relates to a compound according to the following general formula (I), in which: m represents an integer equal to 5, 6 or 7; n and nrepresent an integer from 1 to 5; the A groups represent, in particular, a hydrogenated atom; X represents O or S; Y represents, in particular, a group NR, R, representing, in particular, a hydrogenated atom; W represents CH or N; and Z represents, in particular, a hydrogenated atom.

Cyclodextrin dimers and derivatives thereof, methods for preparing them and their use, in particular, for the solubilizing pharmacologically active substances

The invention relates to a cyclodextrin derivative corresponding to general formula (I) wherein n is a whole number from 1-6, m is a whole number equal to 5, 6 or 7, Ris an OH group, all Rs are identical, Z is a thiourea group, X is a hydrogen atom, and R is a hydrogen atom or a bioidentification element.

Cyclodextrin derivatives, method for the preparation thereof and use thereof for the solubilization of pharmacologically active substances

Region-selective method for preparing cyclodextrin C-6 monosulphonyl derivatives

Thioureido-cyclodextrins, utilized in particular to solubilize

An amphoteric starch containing carboxyl and cationic groups characterized in that its carboxyl groups originate from the selective oxidation of the hemiacetal groups of the cationic starch and possibly of the hemiacetal groups of its products of acid hydrolysis. The process for producing the amphoteric starch consists in reacting a cationic starch in aqueous solution with hydrogen peroxide and hydrobromic acid or bromine, so as to oxidize selectively the hemiacetal groups of the cationic starch and, where appropriate, the hemiacetal groups of its products of acid hydrolysis, to give carboxyl groups.

Amphoteric starch containing carboxyl and cationic groups

This process consists in reacting a cationic starch in aqueous solution with hydrogen peroxide and hydrobromic acid or bromine, so as to oxidize selectively the hemiacetal groups of the cationic starch and, where appropriate, the hemiacetal groups of its products of acid hydrolysis, to give carboxyl groups. The amphoteric starch containing carboxyl and cationic groups, thus obtained, is characterized in that its carboxyl groups originate from the selective oxidation of the hemiacetal groups of the cationic starch and possibly of the hemiacetal groups of its products of acid hydrolysis.

Process for the oxidation of cationic starches and amphoteric starches,

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Saint-Ismier, France

Jacques Defaye