Institut De Recherches Chimiques Et Biologiques Appliquees

Laboratoire Debat

Institut De Recherches Chimiques Et Biologiques Appliquees (i.r.c.e.b.a.)

Societe Dite: Institut De Recherches Chimiques Et Biologiques

Societe Anonyme Dite: Laboratoire Debat

Jacques Debat

Jean Lemoine

Claude Crescioni

Francoise L Gabillault

Monique Longuet

Bernard Guay

Francoise Lier Nee Gabillault

This invention relates to an extract of a Globularia genus plant such as Globularia alypum, Globularia vulgaris and related species of the Globulariaceae family, which is useful as antibrucella, bacteriostatic and antiphlogistic agent. This extract is obtained from the entire plant or a part of said plant by means of two extraction solvents of differing polarity. This extract is useful in human and veterinary therapy, in particular in the treatment of brucellosis.

Globularia extract, its method of preparation and its use as

This invention relates to the preparation of an extract of Inula and related species such as Inula Viscosa and Inula graveolens (which belong to the family compositae) which is useful in therapy, in particular as bacteriostatic and fungistatic agent. This extract is useful in the treatment of human beings suffering from infectious diseases.

Inula extract, its method of preparation and its use as pharmaceutical

This invention is concerned with the preparation of an extract of Stephania cepharantha which is useful in therapy, in particular as bacteriostatic and antiphlogistic and antalgic agent. A therapeutical composition is proposed which contains, in association with a physiologically acceptable excipient, a pharmaceutically effective amount of said Stephania cepharantha extract.

Stephania cepharantha extract, its method of preparation and its use as

This invention is concerned with a therapeutic composition intended in particular for the treatment of secretory disorders of the prostate gland, containing a pharmaceutically active quantity of at least one higher alkanol with 16 or more carbon atoms or one of its esters in association with a physiologically acceptable vehicle.

Higher alkanol compositions and the use thereof in treatment of prostate

The present invention relates to a process for the preparation of an extract of Teucrium marum used in therapy, according to which the whole plant, or part of the plant, is subjected to a treatment with a solvent, the said process being characterized in that the said treatment is carried out with a solvent chosen from among the group comprising boiling water in the presence of NH.sub.3, pentane, hexane, heptane, cyclohexane, cyclopentane, petroleum ether, methylene chloride and mixtures of these, and in that, if necessary, the resulting extract is subjected to a purification.

Process for the preparation of an extract of Teucrium marum used in

The invention relates to novel compounds in the form of epoxy alkanes corresponding to the formula ##STR1## in which B is H or CH.sub.3 and A represents a hydrocarbon radical containing at least 15 carbon atoms. These epoxy alkanes are suitable for therapeutic application, especially in the treatment of secretory disorders of the prostate gland, more especially prostate adenoma.

Compositions for the treatment of disorders of the prostate gland

The specification describes novel 2-(4'-halobenzyl) phenols of the formula: ##SPC1## In which R.sub.1, R.sub.2 and R.sub.3, which may be the same or different, re hydrogen or a lower alkyl group, provided that only one of R.sub.1 , R.sub.2 and R.sub.3 is hydrogen, or any two or R.sub.1, R.sub.2 and R.sub.3 form, together with the carbon atom to which they are attached, a cycloalkyl ring, particularly cyclohexyl, and the third substituent is hydrogen; R.sub.4 is hydrogen, halogen, a nitro group or a benzyl group, the latter, if desired, being substituted in the same manner as the benzyl group shown in the ortho position of the phenolic nucleus; R.sub.5 is hydrogen or a hydroxyl group; X is halogen, particularly chlorine or bromine, and Y is hydrogen or halogen, particularly chlorine or bromine, and a process for their preparation. These compounds have useful bacteriostatic activity.

Growing community of inventors

Saint Cloud, France

Jacques Debat