Roussel Uclaf

Jacques Bulidon

Charles Pavan

Jean Jolly

Giuseppe Gigliotti

A novel process for the resolution of D,L-cis and D,L-trans 2,2-dimethyl-3-(2,2 -dihalovinyl)-cyclopropane-1-carboxylic acids of the formula ##STR1## wherein X is selected from the group consisting of fluorine, chlorine and bromine comprising salifying the said acid with an optically active base selected from the group consisting of D-ephedrine, L-ephedrine, D-N-methyl-ephedrine, L-N-methylephedrine, D-pseudo-ephedrine and L-pseudo-ephedrine to form the corresponding salt, recovering the said salt and subjecting the latter to acid hydrolysis to obtain the corresponding resolved acid which are intermediates for the synthesis of esters having a remarkable insecticidal activity.

Resolution of D,L-cis and D,L-trans

A novel process for the purification of 3.alpha.,7.alpha.-dihydroxy-(5.beta.)-cholanic acid comprising crystallizing the said product from methylene chloride.

Novel purification process

Novel process for the preparation of 4-chloroquinolines of the formula ##STR1## wherein X is in the 5,6,7 or 8-position and is selected from the group consisting of hydrogen, methyl, halogen, CF.sub.3 --, CF.sub.3 O-- and CF.sub.3 S-- by reacting a compound of the formula ##STR2## or a functional derivative thereof with a chlorination agent in the presence of an oxidation agent and to a novel intermediate.

Process for the preparation of 4-chloroquinolines

A process for the resolution of DL-cis chrysanthemic acid or DL-trans chrysanthemic acid with L or D N-methyl-ephedrine to form the corresponding salt and acid hydrolyzing the same which resolved acids are intermediates for preparing esters having a remarkable insecticidal activity.

Resolution process using L or D N-methyl-ephedrine

A novel process for the preparation of racemic allethrolone of the (R,S) configuration comprising heating optically active allethrolone of the (R) configuration or of the (S) configuration or a mixture of the (R) and (S) configurations in non-equimolecular proportions with formic acid to form the formate of racemic allethrolone of (R,S) configuration and hydrolyzing the latter in the presence of an acid or base to obtain racemic (R,S) allethrolone.

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Paris, France

Jacques Bulidon