Hoffmann-la Roche Inc.

F. Hoffmann-la Roche Ag

Jacques Bailly

Jens-Uwe Peters

Philippe Pflieger

Daniel Hunziker

Ulrike Obst Sander

Tanja Schulz-Gasch

Christian D Lerner

Cornelia Hertel

Rainer Eugen Martin

Paul Hadvary

Hans Lengsfeld

Hans Steffen

Roberto Iacone

Susanne Raab

Christoph Patsch

Martin Graf

Osele Ciampi

Andre Fleury

Christian Lerner

This application relates to a method for differentiating pluripotent stem cells (PSCs) into multi-competent renal precursor cells expressing Six2. These renal precursor cells are able to differentiate into fully functional and fully differentiated podocytes. Moreover this application relates to a method for differentiating human embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSCs) into defined renal precursor cells expressing Six2 and podocytes based on linked steps of chemically defined medium inductions.

Method for differentiation of pluripotent stem cells into multi-competent renal precursors

The present invention relates to compounds of formula I wherein A, n, Rto Rand Rto Rare as defined in the description and claims, and pharmaceutically acceptable salts thereof. The compounds are glucocorticoid receptor antagonists useful for the treatment and/or prevention of diseases such as diabetes, dyslipidemia, obesity, hypertension, cardiovascular diseases, adrenal imbalance or depression.

Glucocorticoid receptor antagonists

The present invention relates to compositions and methods for treating obesity. More particularly, the invention relates to a composition comprising a lipase inhibitor such as orlistat, and glucomannan such as konjac as well as methods for utilizing such compositions and kits for carrying out this method.

Anti-obesity compositions

The present invention provides orally administrable pharmaceutical compositions containing an inhibitor of gastrointestinal lipase, and at least one compound selected from the group consisting of chitosan, its derivatives and salts thereof. Methods are provided for preventing and treating anal leakage of oil in a patient to whom a composition containing an inhibitor of gastrointestinal lipase is orally administered.

Pharmaceutical composition containing chitosan

Growing community of inventors

Zimmersheim, France

Jacques Bailly