Other

Jacqueline Sagen

George D Pappas

Harvey B Pollard

Caryl E Sortwell

Mark Perlow

The use of CNS transplants, in particular adrenal medullary transplants, in reducing and/or preventing tolerance to opiates.

Preventing opiate tolerance by cellular implantation

A method for reversing tolerance to opiates by implantation of adrenal medullary cells into the CNS is provided.

Reversing opiate tolerance by cellular implantation

This invention provides a method of alleviating chronic pain in humans. Viable, implantable cells are selected which release neuroactive substances that reduce chronic pain. The cells are cultured to improve their viability, and administered into a region of the central nervous system of a patient who is suffering from chronic pain. The cells continue to secrete the neuroactive substances within the patient without exogenous stimulation. Suitable implantable cells include adrenal medullary tissue cells, chromaffin cells or genetically engineered cells.

Implantable cells that alleviate chronic pain in humans

A novel method for alleviating depression comprises implanting monoamine producing living cells in the CNS of depressive subjects.

Method for alleviating depression

A method of inducing analgesia or reducing pain is described. The method involves implanting in the central nervous system of a host susceptible to pain, living material capable of releasing effective amount of analgesic substance when interacted with a stimulus which induces said material to release analgesic amount of said substance. The procedure described herein reduces sensitivity to intractable pain.

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Chicago, IL, United States of America

Jacqueline Sagen