Yeda Research and Develpment & Co. Ltd

Yissum Research Development Company of the Hebrew University of Jerusalem Ltd.

Jacqueline Libman

Abraham Shanzer

Shneior Lifson

Yoram Shechter

Ioav Zvi Cabantchik

Pharmaceutical compositions comprising hydroxamate derivatives for iron

Vanadyl complexes of hydroxamate chelators and pharmaceutical

There are provided novel compounds useful as selective extractants of metal values from aqueous systems comprising a plurality of such ionic species. There is further provided a process for the production of the novel compounds. The invention also relates to a process of selective metal extraction by means of the novel compounds of the invention.

Extractants for the separation of transition and related metal ions

Ligand compounds useful as extractants of certain metals from solutions. Effective also as promoters of the growth of microorganisms. A process for the preparation of such hexadentate ligands and methods of selective extraction of transition and related metal ions from admixtures with other metals.

Trishydroxamic acids

There are provided novel enterobactin type compounds. There is provided a novel process for the production of enterobactin, and of novel enterobactin type compounds which process is based on the reaction of a serine derivative with a stannoxane of the [BU.sub.2 Sn(OCH.sub.2 CH.sub.2 O)] type. Enterobactin is a known compound of known utility. The novel derivatives are valuable as sequestering agents for iron and other transition metals, for the separation and analysis of same. They can be used as active ingredients in pharmaceutical compositions for the removal of such metals accumulated above an acceptable level in patients.

Enterobactin type compounds

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Rehovot, Israel

Jacqueline Libman