Pharmacia & Upjohn S.p.a.

Pharmacia & Upjohn Company

Farmitalia Carlo Erba S.r.l.

Jacqueline Lansen

Tiziano Bandiera

Antonino Suarato

Michele Caruso

Dario Ballinari

Mario Varasi

Daniele Fancelli

Daniela Faiardi

Steven Paul Tanis

Gabriella Traquandi

Sergio Mantegani

Alberto Bargiotti

Donald Bainbridge Carter

Romeo Roncucci

Allen Edwin Buhl

Thomas J Raub

Gregory J Fici

Geri A Sawada

Luisa Savini

Antonio Molinari

Cesare Pellerano

Marco Gerna

Carla Giorgetti

A method of making antibodies to hirudin by immunizing with an immunogenic composition containing polymerized hirudin monomers in the absence of carrier protein is taught.

Anti-hirudin polyclonal antibodies and their use for the identification, immunopurification and quantitative determination of hirudin

The invention provides methods for diagnosing and treating amyloid-related conditions and compounds useful for the same. The invention provides for detecting, imaging, monitoring, diagnosing, and treating conditions characterized by the binding or aggregation of amyloid fibrils. More particularly, the invention relates to using quinolinehydrazone compounds for diagnosing and treating amyloidotic conditions and also as an antioxidant.

Compounds and methods for diagnosing and treating amyloid-related conditions

A compound of formula (1) wherein R,is hydrogen, hydroxy, a group of formula OR,wherein R,is C,-C,alkyl, C,-C,alkenyl or C,-C,cycloalkyl, halogen, amino which may be unsubstituted or mono or disubstituted by C,-C,alkyl, C,-C,alkenyl, aralkyl, acyl or trifluoroacetyl; R,is hydrogen, hydroxy, a group NR,R,wherein R,and R,independently represent hydrogen, an optionally substituted C,-C,alkyl, C,-C,alkenyl, C,-C,cycloalkyl or, taken together with the nitrogen atom, represent an optionally substituted C,-C,heterocyclic ring; R,is hydrogen, hydroxy, R,is a 2-substituted thiazolyl or imidazolyl system and the pharmaceutically acceptable salt thereof, is useful in the treatment of amyloidosis. Processes for the preparation and pharmaceutical compositions are also described.

Heterocyclyl anthracyclinone derivatives

A compound of formula (1), wherein R,represents hydrogen, hydroxy, a group of formula OR,, wherein R,is C,-C,alkyl, C,-C,alkenyl; R,represents hydrogen, hydroxy, diethylamino, piperidino, tetrahydropyridino or morpholino, and either R,, taken alone, represtnts hydrogen or hydroxy, and R,and R,, taken alone, independently represent hydrogen, hydroxy or, taken together with the carbon atom, represent a carbonyl group; or R,and R,, taken together, represent a group of formula (A), wherein R,and R,represent a C,-C,alkyl and R,represents hydrogen; R,represents hydrogen or a phenyl group, optionally substituted by methyl, methoxy or halogen and the pharnaceutically acceptable salt thereof, is useful in the treatment of amyloidosis. Processes for the preparation and pharmaceutical compositions are also described.

Amino anthracyclinone derivatives and their use in the treatment of amyloidosis

The present invention provides imino aza-anthracyclinones and a method of treating amyloidoses using the same.

Anthracycline derivatives

Fluoro labelled anthracyclinone and anthracycline derivatives

The present invention provides the new use in the treatment of amyloidosis with the anthracyclinone of formula (A) wherein R1, R2, R3, R4, and R5, are appropriate substituents. Some compounds of formula (A) are novel. Processes for their preparation and pharmaceutical composition containing them are also described.

Anthracyclinone derivatives and their use in amyloidosis

Anthracyclinone derivatives

Aza-anthracyclinone derivatives

Use of anthracyclinone derivatives in amyloidosis

Growing community of inventors

Milan, Italy

Jacqueline Lansen