Trustees of the Colorado School of Mines

Colorado State University Research Foundation

Jacqueline L Harding

Melissa D Krebs

Melissa M Reynolds

Megan J Neufeld

The present invention relates to a method for in situ biomimetic mineralization of polymeric hydrogels, where the incorporated CaP phase can be selectively tuned in chemical composition and morphology to mimic bone and dental mineral. The present invention also relates to a method to coat a substrate with apatite material, the resulting product and the use of the product.

Deposition-conversion method for tunable calcium phosphate coatings on substrates and apparatus prepared thereof

The present invention is directed to a method for the tunable precipitation of apatite induced by a chemical reaction within a polymeric hydrogel, and the product made thereof. The present invention includes a pH dependent pathway for the hydrolysis of DCPD precursor phase. In addition to pH the stoichiometry of the CaP reactants can contribute to the composition of the CaP phase incorporated into the PVA hydrogels. At elevated pH the direct conversion of DCPD to apatite is observed. However, decreasing the reaction pH to 7.4 to mimic physiological conditions results in the inclusion of OCP as a transition step.

Controlled and tunable precipitation of biomimetic apatites via in situ mineralization of an organic polymeric matrix

A polymeric composition includes an organic polymeric substrate and metal-organic frameworks on the surface of the polymeric substrate. The metal-organic frameworks cover at least 90% of the surface area of the polymeric substrate.

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Golden, CO, United States of America

Jacqueline L Harding