Amgen Inc.

Jacqueline E Milne

Julio Cesar Medina

Alan Martin Allgeier

Jiwen Liu

Joseph F Payack

Yingcai Wang

An-Rong Li

Matthew Bio

Yongli Su

Thomas Storz

Mark Grillo

Jerry A Murry

Sean H Wiedemann

Eric Fang

Ash Wilsily

Janan Jona

Disclosed herein are methods for preparing [1,2,4]triazolo[4,3-a]pyridines, particularly (R)-6-(1-(8-fluoro-6-(1-methyl-1H-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one, and precursors thereof, such as a method comprising reacting (R)&#x2014;N-(3-fluoro-5-(1methyl-1H-pyrazol-4-yl) pyridin-2-yl)-2-(3-(2-methoxyethoxy)-5-oxo-1,6-naphthyridin-6(5H)yl) propanehydrazide ('HYDZ'): (HYDZ) under conditions sufficient to form (R)-6-(1-(8-fluoro-6-(1-methyl-IH-pyrazol-4-yl)-[1,2,4]triazolo[4,3-a]pyridin-3-yl)ethyl)-3-(2-methoxyethoxy)-1,6-naphthyridin-5(6H)-one ('A'): (A) 

Method for the preparation of [1,2,4]-triazolo[4,3-a]pyridines

Compounds, pharmaceutical compositions and methods are provided that are useful in the treatment of inflammatory and immune-related diseases and conditions. In particular, the invention provides compounds which modulate the function and/or expression of proteins involved in atopic diseases, inflammatory conditions and cancer. The subject compounds are carboxylic acid derivatives.

Phenyl acetic acid derivatives

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Simi Valley, CA, United States of America

Jacqueline E Milne