Abbott Laboratories Corporation

Jacqueline E Briskin

Pramod K Gupta

Susan J Semla

Robert W Kohler

Martin H Yunker

Claud Loyd

David L Schwinke

A process for preparing fine particle pharmaceutical formulations having improved throughput and producing greater uniformity of particle size. The process relates to adding to the dry components of the formulation prior to the steps of wetting, extrusion and spheronization, an extrusion aid material selected from pharmaceutically acceptable oils and waxes having a drop point between about 15.degree. C. and 115.degree. C.

Process for the preparation of fine particle pharmaceutical formulations

Compositions and methods for treating bacterial infections are disclosed. Compositions of a quinolone carboxylic acid or a pharmaceutically acceptable salt or metal ion-acid complex thereof and a polymeric additive that reduces vein irritation upon infusion are described and utilized as antibacterial agents. The compositions of the present invention are parenterally administered to a patient.

Quinolone carboxylic acid compositions with polymeric additive to reduce

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Buffalo Grove, IL, United States of America

Jacqueline E Briskin