Amo Groningen B.v.

Advanced Medical Optics, Inc.

Pharmacia Groningen Bv

Polyganics Bv

Jacqueline De Groot

Kenneth A Hodd

Keith Alfred Dillingham

Albert Johan Pennings

Coenraad Jan Spaans

Folkert Gerhardus Dekens

Methods of producing an intraocular lens include introducing a solution into a lens forming enclosure, wherein the solution comprises discrete crosslinkable units of a size small enough to provide an optically clear solution while contributing to a high refractive index of at least 1.3, performing crosslinking between the units of the solution, and thereby forming a solid lens in the enclosure, optionally under a forming pressure.

Methods of producing intraocular lenses

Methods of producing an intraocular lens in vivo comprise preparing a composition of discrete water soluble macromolecular particles, mixing the composition with a water soluble photoinitiator and forming an opthalmically acceptable aqueous solution having a refractive index of at least 1.39, injecting the resulting aqueous solution into the capsular bag of an eye, and initiating crosslinking between the macromolecular particles by irradiation of a wavelength in the range of about 380 to 700 nm to create a lens in the capsular bag.

Method of producing intraocular lenses in vivo

The invention is directed to a novel biomedical polyurethane based on diisocyanatae linked polyester polymer and diol components, said diol component having a uniform block-length.

Biomedical polyurethane, its preparation and use

A method for producing an intraocular lens, comprising the steps of injecting a high-refractive index, low viscosity composition of crosslinkable units into an enclosure and initiating polymerization under pressure to create a synthetic polymer lens. The method is especially suitable for producing an intraocular lens directly in the capsular bag of the eye from an injected aqueous solution of macromolecular particles, which can undergo a crosslinking reaction to a solid lens when exposed to light.

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Leek, Netherlands

Jacqueline De Groot