Adir Et Compagnie

Albert Rolland S.a.

Les Laboratoires Servier

Adir Et Cie

Science Et Organisation

Science Et Organization

Jacqueline Bonnet

Guillaume De Nanteuil

Michel Wierzbicki

Massimo Sabatini

Charles Tordjman

Armel Fradin

Bernard Portevin

Alain Pierre

Ghanem Atassi

Jean-Daniel Brion

Joseph Paladino

Lucy De Montarby

Frederic Sauveur

Daniel Lesieur

Georges Remond

Pierre A Bessin

Yves Rolland

Gordon Tucker

Luc Demuynck

Pietro Ghezzi

Anne-Marie Chollet

Martine Brisset

Michel Vincent

Gerald Guillaumet

Emmanuel Canet

Jean-Luc Fauchere

Charles Lespagnol

Christine Flouzat

Jacqueline Laforest

Christine Lila

Yannis Tsouderos

Graham Birrell

Christophe Thurieau

Patrick Casara

Thierry Le Diguarher

Guillaume Le Baut

Nicolas Guilbaud

Alain Benoist

Angela D Morris

Guillaume Poissonnet

Marie-Francedillaoise Boussard

Marie-Francoise Boussard

Philippe Pastoureau

Larbi Belachmi

Nathalie Kucharczyk-Gentric

Nathalie Kucharczyk

Anne Marie Chollet

Fr&eacute;d&eacute;ric Sauveur

Nourddine Abdellatifi

Hocine Aichaoui

The invention concerns a compound of formula (I) wherein: n is equal to 0 or 1; R , R , R , R represent a hydrogen or an alkyl group, or R and R together form a cycloalkyl group; R represents a hydrogen, an alkyl, cycloalkyl, cycloalkylalkyl, aryl, arylalkyl, heteroaryl, hetereoalkylalkyl, hetereocycloalkyl, hetereocycloalkylalkyl group (all optionally substituted), or a &mdash;CO&mdash;R group; and R represents R or OR or NR R , with R representing an aryl, arylalkyl, heteroaryl or heteroarylalkyl, heterocycloalkyl, heterocycloalkylalkyl group (all optionally substituted), and R representing an alkyl, aryl, arylalkyl, heteroaryl or heteroarylalkyl (all optionally substituted); or R and R form with the nitrogen atom and the Z group bearing them a saturated monocyclic, bicyclic or tricyclic group, partially unsaturated or unsaturated, with 5 to 16 chain links containing 1 to 7 heteroatoms and optionally substituted; R represents a hydrogen atom or a hydroxy group, and in the latter case R , R , R , R are independently selected among hydrogen and alkyl; Z represents a hydroxy, alkoxy, alkenyloxy, benzyloxy group or a NH&mdash;OR group; X represents a sulphur, a SO, SO group (in those cases where R and R are different from an alkyl) or a group &mdash;CO&mdash;O&mdash; (in which case R and R form a cycloalkyl group), or X represents an oxygen atom; W represents a W &mdash;(A) or W &mdash;B&mdash;W &mdash;(A) group wherein W and W represent an aryl or heteroaryl group, A is a standard substituent of aromatic cycles, B a bond, an oxygen or an alkylene, alkenylene, alkynylene group, and p is an integer ranging between 0 and 5; T and T represent a bond or an alkylene, alkenylene, or alkynylene group. The invention is useful for preparing medicines.

Carboxylic and hydroxamic acid compounds inhibiting metalloproteases, method for preparing same and pharmaceutical compositions containing them

Metalloprotease inhibitors

The invention relates to thiophene compounds of formula:

Thiophene compounds

Compounds of formula (I): ##STR1## wherein: R represents hydrogen, alkyl, optionally-substituted amino, or linear or branched (C.sub.1 -C.sub.6)-acyl,

Pyrrole compounds

Compound of formula (I): ##STR1## in which: m represents an integer from 1 to 4 inclusive, and n and p an integer from 0 to 4 inclusive,

Metalloproteinase inhibitors

A compound of formula (I): ##STR1## wherein: R.sub.1 represents halogen or a different group as defined in the description,

Benzimidazole, benzoxazole and benzothiazole compounds

A compound of formula (I): ##STR1## in which: R.sub.1 represents halogen or hydroxyl, alkoxy, trihalomethyl, amino, mercapto, alkylthio, trialkylammonium, aryloxy, arylthio, arylsulfonyl, arylsulfonyloxy, cycloalkyloxy, cycloalkylthio, bicycloalkyloxy or bicycloalkylthio,

Compound of formula (I): ##STR1## in which: m, n, which are identical or different, represent 0, 1 or 2,

The invention relates to thiophene compounds of formula: ##STR1## wherein: X.sub.1, X.sub.2, Y.sub.1 and Y.sub.2, which are identical or different, each represents hydrogen or halogen, (C.sub.1 -C.sub.5)-alkyl or

Thiophene compounds of formula: ##STR1## wherein R.sub.1, R.sub.2 and R.sub.3 are as defined in the description, and salts thereof with appropriate acids. Those compounds and their physiologically tolerable salts can be used as medicaments in the treatment of pathologies characterized by a loss of bone tissue.

The invention provides new compounds pertaining to the class of: 2-(aminocarbonylalkylcarbonyl)-5-phenylalkyllthiophene, enantiomers and physiologically tolerable salts thereof. For example:

A compound of formula (I): ##STR1## in which X, n, B and Y are as defined in the description. useful as cytokine inhibitors.

Heterocyclic compounds

The invention relates to the compounds of formula (I): ##STR1## in which: R.sub.1 represents alkyl, phenyl, naphthyl, pyridyl or thienyl group, each phenyl, naphthyl, pyridyl or thienyl optionally being substituted,

Piperidine compounds

New benzothiazine derivatives corresponding to the general formula I: ##STR1## in which: X represents halogen,

Phenothiazine cytokine inhibitors

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Paris, France

Jacqueline Bonnet