Dr. Karl Thomae Gmbh

Karl Thomae Gmbh

Jacobus C Antonius Van Meel

Norbert Hauel

Wolfgang Wienen

Uwe Joerg Ries

Michael Entzeroth

Gerhard Mihm

Berthold Narr, Deceased

Angiotensin-II antagonists of the formula ##STR1## wherein R.sub.1 is, other than hydrogen and, inter alia, halogen, lower alkyl or cycloalkyl; R.sub.2 is, inter alia, optionally substituted benzimidazol-2-yl, 5,6,7,8-tetrahydro-imidazo[1,2-a]pyridin-2-yl, butanesultam-1-yl, imidazol-4-yl, and tetrahydobenzimidazol-2-yl; R.sub.3 is, inter alia, lower alkyl; and, R.sub.4 is an acidic group, such as carboxyl or tetrazolyl. An exemplary compound is: 4'-[(2-n-propyl-4-methyl-6-(1-(2-N-morpholinoethyl)-imidazol-4-yl)-benzimi dazol-1-yl)-methyl]-biphenyl-2-carboxylic acid.

(1-(2,3 or

Angiotensin-II inhibiting benzimidazoles, useful for the treatment of hypertension. Exemplary compounds are:

Benzimidazoles and pharmaceutical compositions containing them

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Munich, Georgia

Jacobus C Antonius Van Meel