Duphar International Research Bv

Other

Jacobus A Den Hartog

Ineke Van Wijngaarden

Herman H Van Stuivenberg

Martinus T Tulp

Josephus H Lange

Cornelis G Kruse

Roelof W Feenstra

Stephen K Long

Gerrit P Toorop

Donald T Witiak

Raghunathan V Nair

Ineke V Wijngaarden

A group of new piperazine and piperidine compounds having interesting advantageous pharmacological properties and have the formula (a) ##STR1## wherein A represents a heterocyclic group having 5-7 ring atoms wherein 1-3 heteroatoms selected from the group O, N and S are present,

Piperazine and piperidine compounds

The present invention relates to compounds having anti-ischaemic activity of the formula ##STR1## wherein R.sub.1, R.sub.2, R.sub.3, R.sub.4, R.sub.5 and Z are as defined herein. The present invention further relates to a method of preparing such compounds, as well as compositions having anti-ischaemic activity which comprise such compounds and a method of treating ischaemia.

Phenylalkyl amine derivatives having anti-ischaemic activity

The invention relates to compounds having anti-ischaemic activity, memory enhancing activity and anti-convulsive activity of the formulae 1A and 1B ##STR1## wherein R.sub.1 +R.sub.2 together form an alkylene group having 1-3 C-atoms which may be substituted with one or more alkyl group(s) having 1-3 C-atoms and the remaining R and Z variables are defined as disclosed herein, or a pharmacologically acceptable salt thereof.

Alkylenedioxyphenyl ether derivatives having anti-ischaemic, memory

The invention relates to a group of new 1,4-diazepine derivatives of the formula ##STR1## wherein A represents a group of the formulae 2-10 ##STR2## These compounds have a strong anti-ulcer activity after oral administration.

1,4-diazepine derivatives having anti-ulcer activity

The invention relates to a group of tertiary 2,5-dialkyl-3-phenylpiperidine derivatives, having opiate-antagonistic activity represented by general formula 4, ##STR1## wherein A.sub.1 is hydrogen, an optionally esterified hydroxyl group or mercapto group, a group NHA.sub.8 or --CONHA.sub.8, wherein A.sub.8 is hydrogen, alkyl having 1-6 C-atoms or alkylcarbonyl having 2-7 C-atoms;

Tertiary 2,5-dialkyl-3-phenylpiperidine derivatives having

New 1,4-diazepine derivatives having anit-ulcer activity

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Weesp, Netherlands

Jacobus A Den Hartog