Emit Imaging, Inc.

Invicro, LLC

Other

Biogen Ma Inc.

Jacob Yost Hesterman

John William Hoppin

Marc Edward Seaman

Robert William Holt

Mohammed Q Qutaish

John V Frangioni

Mark W Bordo

Kelly Davis Orcutt

Christian Lackas

Ajay Verma

Jack Hoppin

A fluorescence histo-tomography (FHT) method may include capturing, using an imaging device positioned with respect to a chamber of a slicing apparatus, images of a block face of a specimen retained within the chamber. The images may be captured in the visible and infrared or near-infrared spectrum. The method may include co-registering the images to form a combined image, and providing the combined image to an electronic display. In some implementations, the method may include positioning the imaging device away from the chamber, operating the slicing apparatus to expose a second block face of the specimen, and repositioning the imaging device with respect to the chamber.

Fluorescence histo-tomography (FHT) systems and methods

Wearable apparatus and method of using same for tracking a labeled probe in a subject are disclosed.

Assessment of labeled probes in a subject

In one embodiment, a fluorescence histo-tomography (FHT) system is disclosed. The FHT system includes an imaging housing, a fluorescence camera located within the housing, a white light camera located within the imaging housing, and a fluorescence light source located within the imaging housing. The FHT system further includes a support mount configured to support the imaging housing within a chamber of a slicing apparatus such that the cameras and fluorescence light source are aimed towards a block face of a tissue specimen retained within the chamber.

In one embodiment, a fluorescence histo-tomography (FHT) system is disclosed. The FHT system includes a housing, a fluorescence camera located within the housing, a white light camera located within the housing, and a fluorescence light source located within the housing. The FHT system further includes a support mount configured to support the housing within a chamber of a slicing apparatus such that the cameras and fluorescence light source are aimed towards a block face of a tissue specimen retained within the chamber.

Disclosed is a computer-implemented method of creating an image of a specimen including receiving a first image of a first section of a specimen created using a first wavelength of invisible light a second image of a second section of the specimen adjacent to the first section and the second image created using the first wavelength of invisible light, co-registering the first image and the second image and creating, by the processor, a single-plane image of the first section using a next-image process.

Multi-spectral three dimensional imaging system and method

A method of estimating a parameter of physiological significance in the central nervous system (CNS) is provided. The method comprises (a) providing one or more images of the brain or cerebral spinal fluid (CSF) in a subject to whom a dose of a contrast agent (CA) has been administered; (b) determining, using a computer equipped with image processing software, the concentration or relative concentration of the agent in a region or regions of interest in the brain or CSF, thereby generating concentration data; (c) describing the time-based behavior of concentrations of CA within the brain or CSF using a pharmacokinetic model that is based on a set of pharmacokinetic model parameters; and (d) fitting, using computer code, the pharmacokinetic model to the concentration data, varying one or more parameters, wherein the best fit estimates a parameter of physiological significance in the CNS.

Estimating pharmacokinetic parameters in imaging

A method is provided for estimating a parameter of physiological significance. One or more images are provided of a tissue in a subject to whom a dose of a contrast agent (CA) has been administered, using a computer equipped with image processing software, the concentration or relative concentration of the agent in a region or regions of interest in the tissue is determined, thus generating concentration data. The time-based behavior of concentrations of CA within the tissue is determined using a pharmacokinetic model that is based on a set of pharmacokinetic model parameters. Using computer code, the pharmacokinetic model is fit to the concentration data, varying one or more parameters, such that a best fit estimate of a parameter of physiological significance is provided.

Growing community of inventors

Newton, MA, United States of America

Jacob Yost Hesterman