Profusa, Inc.

Jacob William Clary

Soya Gamsey

Sulolit Pradhan

Alex Kutyavin

Viachaslau Bernat

Natalie Wisniewski

Scott Nichols

Mary K Balaconis

Sierra Guidry

Yu Zhang

Ryan Schweller

Glucose-sensing luminescent dyes of formula (IV-I), polymers, and sensors are provided. Additionally, systems including the sensors and methods of using these sensors and systems are provided.

Near-IR glucose sensors

Some embodiments described herein relate to a sensor that includes a first a first polymer-luminescent sensing compound configured to produce a first luminescent signal in the presence of a first analyte and a second polymer-luminescent sensing compound configured to produce a second luminescent signal in the presence of a second analyte. The second luminescent signal can have a luminescent lifetime that is at least 1.1 times greater than a luminescent lifetime of the first luminescent signal. Such temporally differences in signal can be used to deconvolute the first luminescent signal from the second luminescent signal even when, for example, the first luminescent signal and the second luminescent signal have the same or a similar emission spectrum.

Multi-analyte sensing tissue-integrating sensors

The present invention is directed, in certain embodiments, to polymerizable near-IR dyes and polymers comprising said dyes as monomeric residues. In other embodiments, the present invention also relates to methods for the preparation of polymerizable near-IR dyes, and to the use of polymerizable near-IR dyes in the preparation of fluorescent polymers.

Polymerizable near-IR dyes

The present disclosure provides polymerizable luminescent dyes useful for incorporation into polymers. The dyes and the polymers can be used in sensing and imaging applications, for example, to provide accurate and optionally long term measurements of glucose in vivo. The present disclosure also provides sensors including the polymers described herein. The sensors can be implanted into a tissue of a subject and used for long-term or short-term continuous and semi-continuous collection of data of various biochemical analytes, optionally without the use of implantable hardware of any type and/or enzymatic and electrochemical detection methods.

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Moss Beach, CA, United States of America

Jacob William Clary