Massachusetts Institute of Technology

Becton Dickinson and Company Limited

The Brigham and Women's Hospital, Inc.

Other

Novo Nordisk A/s

Jacob Wainer

Robert Samuel Langer

Carlo Giovanni Traverso

Victor Isaac Politis

Alex G Abramson

Alex Chaves

John Perez

Michael Scott Williams

James Gordon McLean

Kevin Franklin King

Niclas Roxhed

Brian Mouridsen

Daniel Robert Carson

Doug Scott

Jorrit Jeroen Water

Richard Bucchianeri

James M Kinsey

Yi Lu

Jason M Geller

Drago Sticker

Susan Haverstick

Larion Johnson

Torben Sebastian Last

Graham Arrick

Ilir Kumi

Siheng You

Michael Williams

Jonathan Magee

Declan Gwynne

Jacob Pyung Hwa Jepsen

Bozhidar Nikolaev Kozhuharov

William Coburn

Katelyn Sweeney

Kim Frandsen

Alex Krasa

Cody Cleveland

Douglas Laderman

Adam Azanow

Adam Bohr

Aghiad Ghazal

Alex Petrovsky

Nicholas Exarchos

Olivia Van Amsterdam

Nickolas Thorsen

Chris Williamson

Russell Forrest

Ethan Ziegler

Ford Grundberg

Kimya Harper

A strain relief adapter () for a medicament delivery device () includes a flexible body () having a first end () configured to connect to one of a fluid connector and a pump connector, a second end () configured to connect to tubing, a hollow fluid path () therethrough fluidly connecting the first and second ends, and a plurality of external strain relief ridges () disposed between the first and second ends.

Strain relief adapter for medical tubing connection

A medicament delivery device having a reservoir for holding a medicament, a pressurizing system that dispenses the medicament from the reservoir when operating, a hollow cannula for insertion into a patient, and a fluid delivery path disposed between the pressurizing system and the hollow cannula and communicating the medicament therebetween. The medicament delivery device also has a pressure sensor external to the pressurizing system, sensing a back pressure in the fluid delivery path, and providing an indication when the back pressure drops below a predetermined threshold after the pressurizing system ceases operation.

Pressure indicator for medicament delivery device

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface. In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent. In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent.

Self-righting systems, methods, and related components

A drug delivery device for administration to a subject is provided. In some embodiments, the drug delivery device includes a reservoir containing an active pharmaceutical ingredient and a potential energy source. The drug delivery device also includes a trigger operatively associated with the potential energy source, where the trigger is configured to actuate at a predetermined location within the subject. The drug delivery device also includes a rupturable membrane disposed along a flow path extending between the reservoir and an outlet, where the membrane is configured to rupture when the trigger is actuated. Once the trigger is actuated, the potential energy from the potential energy source may be released to expel the active pharmaceutical ingredient in a jet through the outlet.

Drug delivery device

Self-righting articles, such as self-righting capsules for administration to a subject, are generally provided. In some embodiments, the self-righting article may be configured such that the article may orient itself relative to a surface (e.g., a surface of a tissue of a subject). The self-righting articles described herein may comprise one or more tissue engaging surfaces configured to engage (e.g., interface with, inject into, anchor) with a surface (e.g., a surface of a tissue of a subject). In some embodiments, the self-righting article may have a particular shape and/or distribution of density (or mass) which, for example, enables the self-righting behavior of the article. In some embodiments, the self-righting article may comprise a tissue interfacing component and/or a pharmaceutical agent (e.g., for delivery of the active pharmaceutical agent to a location internal of the subject). In some cases, upon contact of the tissue with the tissue engaging surface of the article, the self-righting article may be configured to release one or more tissue interfacing components. In some cases, the tissue interfacing component is associated with a self-actuating component. For example, the self-righting article may comprise a self-actuating component configured, upon exposure to a fluid, to release the tissue interfacing component from the self-righting article. In some cases, the tissue interfacing component may comprise and/or be associated with the pharmaceutical agent (e.g., for delivery to a location internal to a subject).

The invention relates to remotely operated multi-component search robots for underwater search and rescue operations, and particularly suited for searches under ice.

Multi-component robot for below ice search and rescue

Growing community of inventors

Medford, MA, United States of America

Jacob Wainer