Cb Therapeutics, Inc.

Other

Jacob Michael Vogan

Sher Ali Butt

Erin Marie Scott

James Wade

Tyrone Jacob Yacoub

Laura Flatauer Peiffer

Kirsten Tang

Rachel Nadine Burnett

The methods and systems disclose enzymes that function to import malonic acid or malonates into a cell. The enzymes increase the output of precursor molecules by enriching certain pathways in the cell. The precursor molecules can be converted to cannabinoids. The enzymes are a family of proteins which have a majority of common alignments.

Malonate transporters

The systems and methods herein include engineering a host to produce psilocybin using engineered enzymes, genetic changes, and exogenous psilocybin precursor addition (e.g., addition of L-tryptophan to a growing culture of a psilocybin producing recombinant host strain). The process occurs in genetically engineered host cell(s) that can produce psilocybin.

Biosynthetic production of psilocybin and related intermediates in recombinant organisms

The present invention is a method for the biosynthesis of hundreds of compounds, mainly found in theplant. The starting material for these compounds can be any biological compound that is used/produced in a biological organism from the sugar family starting materials or other low cost raw materials processed via enzymes or within organisms to give final products. These final products include, but are not limited to: cannabinoids, terpenoids, stilbenoids, flavonoids, phenolic amides, lignanamides, spermidine alkaloids, and phenylpropanoids. Specifically, the present invention relates to the regular, modified, or synthetic gene(s) of select enzymes that are processed and inserted into an expression system (for example, a vector, cosmid, BAC, YAC, phage) to produce modified hosts. The modified host is then optimized for efficient production and yield via manipulation, silencing, and amplifying inserted or other genes in the host, leading to an efficient system for product.

Isolated codon sequence

Methods for increasing production of cannabinoids in yeast cells

The present invention is a method for the biosynthesis of hundreds of compounds, mainly found in theplant. The starting material for these compounds can be any biological compound that is used/produced in a biological organism from the sugar family starting materials or other low cost raw materials processed via enzymes or within organisms to give final products. These final products include, but are not limited to: cannabinoids, terpenoids, stilbenoids, flavonoids, phenolic amides, lignanamides, spermidine alkaloids, and phenylpropanoids. Specifically, the present invention relates to the regular/modified/synthetic gene(s) of select enzymes are processed and inserted into an expression system (vector, cosmid, BAC, YAC, phage, etc.) to produce modified hosts. The modified host is then optimized for efficient production and yield via manipulation, silencing, and amplifying inserted or other genes in the host, leading to an efficient system for product.

Isolated codon optimized nucleic acid

A cooking utensilhaving a stem or handleand a bowl or containment portionwhich has a cavityand protruding ridges which may be used to selectively engage, cut and grind an item such as food.

Growing community of inventors

San Diego, CA, United States of America

Jacob Michael Vogan