Revance Therapeutics, Inc.

Candesant Biomedical, Inc.

Leland Stanford Junior University

Precision Dermatology, Inc.

Jacob M Waugh

Michael D Dake

Curtis L Ruegg

Christopher Elkins

Stewart A Thompson

Hyop Rhee

Hongran Fan Stone

Michael O'Neil

Niquette Hunt

Jesse Rosen

Jae Hoon Lee

Pamela Cifra

Hongran F Stone

This invention provides methods to treat or prevent cervical dystonia, a disorder related thereto, or a symptom thereof, with novel injectable compositions comprising botulinum toxin that may be administered to a subject suffering from such maledy. The injectable compositions and methods in which these compositions are used provide novel and advantageous treatments which result in high responder rates and long duration of effect, for example, a duration of effect for 24 weeks and longer.

Methods of treatment for cervical dystonia

A device for a medical or cosmetic treatment based on heat is provided. The device includes an impermeable backing layer and an adhesive layer in contact with the backing layer. The device also includes an alkali metal selected from a single, free alkali metal and an alloy alkali metals, the alkali metal in contact with at least a portion of the adhesive layer to define a treatment region. The device also includes a release liner in contact with the adhesive layer and the treatment region. A heat delivery system or kit including the device and a method for its use are also provided.

Medical devices for generating heat and methods of treatment using the same

A device comprising a heat-generating component that comprises an alkali metal is provided. The alkali metal in the presence of water at a point of contact of the device undergoes an exothermic reaction to generate heat in situ. The amount of heat generated is proportional to and/or limited by the amount (or moles) of water at the point of contact, and the heat generated is sufficient to achieve an increase in temperature at the point of contact to achieve a therapeutic or beneficial result. In one embodiment, the device is used for reducing sweat production in a subject suffering from excessive sweating or hyperhidrosis. In other embodiments, the device is used to substantially sterilize a surface or render a surface substantially aseptic.

Medical devices for generating heat and methods of treatment using same

This invention relates to botulinum toxin formulations that are stabilized without the use of any proteinaceous excipients. The invention also relates to methods of preparing and using such botulinum toxin formulations.

Albumin-free botulinum toxin formulations

This invention provides novel injectable compositions comprising botulinum toxin that may be administered to a subject for various therapeutic, aesthetic and/or cosmetic purposes. The injectable compositions contemplated by the invention exhibit one or more advantages over conventional botulinum toxin formulations, including reduced antigenicity, a reduced tendency to undergo unwanted localized diffusion following injection, increased duration of clinical efficacy or enhanced potency relative, faster onset of clinical efficacy, and/or improved stability.

Injectable botulinum toxin formulations

This invention relates totoxin formulations that are stabilized without the use of any proteinaceous excipients. The invention also relates to methods of preparing and using suchtoxin formulations.

Improved formulations for transdermal delivery of botulinum toxin are disclosed. The formulations include, for example, botulinum toxin non-covalently associated with a positively charged backbone having branching or efficiency groups. The formulations also include a partitioning agent, oligo-bridge, or polyanion bridge, and may optionally contain a viscosity modifying agent. The formulations are designed for topical application onto the skin of a patient and may be used to treat wrinkles, hyperhidrosis, and other health-related problems. Kits for administration are also described.

Compositions and methods for topical application and transdermal delivery of botulinum toxins

Methods for treating rhinitis in a subject are provided herein. The methods of the present invention comprise intranasal administration of a topical composition comprising a purifiedneurotoxin, a carrier and a viscosity modifier to one or more inner surfaces of the nose. The methods disclosed herein provide alternative methods for delivery ofneurotoxin to the nasal anatomy for the treatment of rhinitis.

Compositions and methods for safe treatment of rhinitis

Compositions and methods are provided that are useful for the delivery, including transdermal delivery, of biologically active agents, such as non-protein non-nucleotide therapeutics and protein-based therapeutics excluding insulin, botulinum toxins, antibody fragments, and VEGF. The compositions and methods are particularly useful for topical delivery of antifungal agents and antigenic agents suitable for immunization. Alternatively, the composition can be prepared with components useful for targeting the delivery of the compositions as well as imaging components.

Compositions and methods for topical diagnostic and therapeutic transport

Improved formulations for transdermal delivery oftoxin are disclosed. The formulations include, for example,toxin non-covalently associated with a positively charged backbone having branching or efficiency groups. The formulations also include a partitioning agent, oligo-bridge, or polyanion bridge, and may optionally contain a viscosity modifying agent. The formulations are designed for topical application onto the skin of a patient and may be used to treat wrinkles, hyperhidrosis, and other health-related problems. Kits for administration are also described.

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Mountain View, CA, United States of America

Jacob M Waugh