Lockheed Martin Corporation

Lockheed Martin Corpora Tion

Jacob Louis Swett

Peter V Bedworth

Steven W Sinton

Sarah M Simon

Scott E Heise

John B Stetson, Jr

Gregory Scott Bruce

Arul Manickam

Peter G Kaup

Wilbur Lew

Joseph W Hahn

Han Liu

Thomas J Meyer

Steven L Sinsabaugh

David Nelson Coar

Jon Carmelo Russo

Randall Mark Stoltenberg

Steven Edward Bullock

Duc Huynh

Andrew Raymond Mandeville

Julie Lynne Miller

Bryan Neal Fisk

James Michael Krause

Stephen Michael Sekelsky

Nicholas Mauriello Luzod

Kenneth Michael Jackson

Jay T Hansen

John B Stetson

Padraig Moloney

Michael J Hiltabidle

Michael John Dimario

Joseph A Villani

Anjaney Pramod Kottapalli

Gary Edward Montgomery

Margaret Miller Shaw

David Francis Casey, Jr

Two-dimensional materials, particularly graphene-based materials, having a plurality of apertures thereon can be formed into enclosures for various substances and introduced to an environment, particularly a biological environment (in vivo or in vitro). One or more selected substances can be released into the environment, one or more selected substances from the environment can enter the enclosure, one or more selected substances from the environment can be prevented from entering the enclosure, one or more selected substances can be retained within the enclosure, or combinations thereof. The enclosure can for example allow a sense-response paradigm to be realized. The enclosure can for example provide immunoisolation for materials, such as living cells, retained therein.

Methods for in vivo and in vitro use of graphene and other two-dimensional materials

Modified substrates are provided having nano- or microscale wells, tracks, channels, pores or perforations. Also provided are methods of making the same.

Modified track-etched substrates for composite graphene membranes

Multi-layer sheets of graphene-based material having a plurality of pores extending therethrough are described herein. Methods for making the sheets are also provided and include exposing a graphene-based material comprising multilayer graphene having from 2 to 10 layers of graphene to a particle beam comprising nanoparticles, the nanoparticles having an energy of at least 2 keV per nanoparticle.

Nanoparticle modification and perforation of graphene

A system for magnetic detection includes a magneto-optical defect center material including at least one magneto-optical defect center that emits an optical signal when excited by an excitation light; a radio frequency (RF) exciter system configured to provide RF excitation to the magneto-optical defect center material; an optical light source configured to direct the excitation light to the magneto-optical defect center material; and an optical detector configured to receive the optical signal emitted by the magneto-optical defect center material.

Magneto-optical detecting apparatus and methods

Various systems and methods relating to two-dimensional materials such as graphene. A membrane include a cross-linked graphene platelet polymer that includes a plurality of cross-linked graphene platelets. The cross-linked graphene platelets include a graphene portion and a cross-linking portion. The cross-linking portion contains a 4 to 10 atom link. The cross-linked graphene platelet polymer is produced by reaction of an epoxide functionalized graphene platelet and a (meth)acrylate or (meth)acrylamide functionalized cross-linker.

Two-dimensional materials and uses thereof

It can be difficult to remove atomically thin films, such as graphene, graphene-based material and other two-dimensional materials, from a growth substrate and then to transfer the thin films to a secondary substrate. Tearing and conformality issues can arise during the removal and transfer processes. Processes for forming a composite structure by manipulating a two-dimensional material, such as graphene or graphene-base material, can include: providing a two-dimensional material adhered to a growth substrate; depositing a supporting layer on the two-dimensional material while the two-dimensional material is adhered to the growth substrate; and releasing the two-dimensional material from the growth substrate, the two-dimensional material remaining in contact with the supporting layer following release of the two-dimensional material from the growth substrate.

Processes for forming composite structures with a two-dimensional material using a porous, non-sacrificial supporting layer

Sheets of graphene-based material comprising single layer graphene and suitable for formation of a plurality of perforations in the single layer graphene are provided. In an aspect, the sheets of graphene-based material are formed by chemical vapor deposition followed by one or more conditioning steps. In a further aspect, the sheets of graphene-based material include non-graphenic carbon-based material and may be characterized the amount, mobility and/or volatility of the non-graphenic carbon-based material.

Perforatable sheets of graphene-based material

Some embodiments comprise membranes comprising a first layer comprising a porous graphene-based material; a second layer comprising a porous graphene-based material; a channel positioned between the first layer and the second layer, wherein the channel has a tunable channel diameter; and at least one spacer substance positioned in the channel, wherein the spacer substance is responsive to the environmental stimulus. In some cases, the membranes have more than two layers of porous graphene-based material. Permeability of a membrane can be altered by exposing the membrane to an environmental stimulus. Membranes can be used in methods of water filtration, immune-isolation, timed drug release (e.g., sustained or delayed release), hemodialysis, or hemofiltration.

Membranes with tunable selectivity

A method and system for detecting a target molecule. The method includes allowing a fluid containing the target molecule to pass by a complementary moiety attached to a paramagnetic ion so as to cause the complementary moiety and the paramagnetic ion to change a position. A magnetic effect change caused by the change in position of the paramagnetic ion is detected. The target molecule is identified based on the identity of the complementary moiety and the detected magnetic effect change.

Spin relaxometry based molecular sequencing

Production of perforated two-dimensional materials with holes of a desired size range, a narrow size distribution, and a high and uniform density remains a challenge, at least partially, due to physical and chemical inconsistencies from sheet-to-sheet of the two-dimensional material and surface contamination. This disclosure describes methods for monitoring and adjusting perforation or healing conditions in real-time to address inter- and intra-sheet variability. In situ or substantially simultaneous feedback on defect production or healing may be provided either locally or globally on a graphene or other two-dimensional sheet. The feedback data can be used to adjust perforation or healing parameters, such as the total dose or efficacy of the perforating radiation, to achieve the desired defect state.

Methods for in situ monitoring and control of defect formation or healing

A two-dimensional membrane layered structure may include a support substrate layer having a plurality of substrate passages configured to allow fluid to flow therethrough, a two-dimensional membrane layer disposed on an upper surface of the support substrate layer, and a plurality of flow passages disposed between the support substrate layer and the two-dimensional membrane layer. The two-dimensional membrane layer may have a plurality of pores configured to allow fluid to flow therethrough. The plurality of pores may comprise a first portion of pores that overlap with the plurality of substrate passages and a second portion of pores that do not overlap with the plurality of substrate passages. The plurality of flow passages may be configured to allow fluid to flow through the second portion of pores to the plurality of substrate passages.

Two-dimensional membrane structures having flow passages

A method for transferring a graphene sheet from a copper substrate to a functional substrate includes forming the graphene sheet on the copper substrate using chemical vapor deposition, and irradiating the graphene sheet disposed on the copper substrate with a plurality of xenon ions using broad beam irradiation to form a prepared graphene sheet. The prepared graphene sheet is resistant to forming unintentional defects induced during transfer of the prepared graphene sheet to the functional substrate. The method further includes removing the copper substrate from the prepared graphene sheet using an etchant bath, floating the prepared graphene sheet in a floating bath, submerging the functional substrate in the floating bath, and decreasing a fluid level of the floating bath to lower the prepared graphene sheet onto the functional substrate.

Method for treating graphene sheets for large-scale transfer using free-float method

Perforated graphene and other perforated two-dimensional materials can be used in hemodialysis membranes and blood filtration membranes for selective removal of components from blood in vivo and ex vivo. The membranes are useful in hemodialysis and hemofiltration techniques to provide improved patient care. Hemodialysis systems can include a hemodialysis membrane formed from perforated graphene or another perforated two-dimensional material disposed upon a porous support structure. Hemofiltration systems can include one or more and preferably two or more blood filtration membrane formed from perforated graphene or another perforated two-dimensional material disposed upon a porous support structure. Methods for performing hemodialysis can involve exposing blood from a patient to a hemodialysis membrane formed from a perforated two-dimensional material. Ex vivo dialysis techniques can be performed similarly. Methods for filtration of blood can involve passing blood through one or more filter membranes or through a plurality of sequential filter membranes.

Hemodialysis and hemofiltration membranes based upon a two-dimensional membrane material and methods employing same

Multi-layer sheets of graphene-based material having a plurality of pores extending therethrough are described herein. Methods for making the sheets include exposing a graphene-based material comprising multilayer graphene having from 5 to 20 layers of graphene to a particle beam having an ion energy of at least about 1500 eV to create damage tracks in the graphene sheets. The damage tracks in the graphene sheets are then exposed to a chemical etchant, such as an oxidant to define pores through the stacked graphene sheets. Production of the damage tracks and etching of the damage tracks can take place while the graphene is disposed on a substrate.

Methods for perforating multi-layer graphene through ion bombardment

Perforated graphene sheets can be used in forming separation membranes. Separation membranes of the present disclosure, which can be used in gas separation processes in some embodiments, can include one or more layers of perforated graphene and one or more layers of another membrane material. Methods for separating a gas mixture can include contacting a gas mixture with the separation membranes, and transiting one or more of the gases through the perforated graphene so as to affect separation.

Growing community of inventors

Redwood City, CA, United States of America

Jacob Louis Swett