Columbia University

Brown University

Jacob Karl Rosenstein

Kenneth Shepard

Christopher Rose

Jingyue Ju

Zengmin Li

Shiv R Kumar

James J Russo

Sergey M Kalachikov

Minchen Chien

Chuanjuan Tao

Ken Shepard

Jason K Sello

Sherief Reda

Hokchhay Tann

Peter M Weber

Eunsuk Kim

Kady M Oakley

Brenda Rubenstein

Christopher Arcadia

Amanda Doris Dombroski

Shui Ling Chen

Joseph D Geiser

Eamonn Kennedy

Ryan Michael Field

Siddharth Ramakrishnan

Jared Roseman

Shanshan Dai

Dan Fleischer

This disclosure is related to a method of sequencing a single-stranded DNA using deoxynucleotide polyphosphate analogues and translocation of tags from incorporated deoxynucleotide polyphosphate analogues through a nanopore.

DNA sequencing by synthesis using modified nucleotides and nanopore detection

A system includes an array of chemical, pressure, and temperature sensors, and a temporal airflow modulator configured to provide sniffed vapors in a temporally-modulated sequence through a plurality of different air paths across multiple sensor locations.

Multi-parametric machine olfaction

The invention provides methods for computing with chemicals by encoding digital data into a plurality of chemicals to obtain a dataset; translating the dataset into a chemical form; reading the data set; querying the dataset by performing an operation to obtain a perceptron; and analyzing the perceptron for identifying chemical structure and/or concentration of at least one of the chemicals, thereby developing a chemical computational language. The invention demonstrates a workflow for representing abstract data in synthetic metabolomes. Also presented are several demonstrations of kilobyte-scale image data sets stored in synthetic metabolomes, recovered at &#x3e;99% accuracy.

Methods of chemical computation

A system and method for detecting a single-molecule using an integrated circuit which includes at least one membrane having a nanopore located between first and second reservoirs and a low-noise preamplifier having an electrode formed on the surface thereof is provided. The method includes passing a target molecule through the nanopore, and measuring a current through the nanopore to detect the presence of a biomolecular entity, if any.

Systems and methods for single-molecule detection using nanopores

Method for interfacing an integrated circuit with a biological ion channel, the integrated circuit being at least partially disposed within an electrolytic solution and including an amplifier and one or more electrodes on a surface thereof, includes forming one or more microwells proximate the one or more electrodes, applying a lipid membrane over the integrated circuit proximate the microwells, and placing a further electrode in the electrolytic solution proximate the lipid membrane on a side opposite the integrated circuit. A biological ion channel interface is also provided.

Systems and methods for biological ion channel interfaces

A system for high-speed molecular diagnostics includes a self-resetting continuous-time integrator configured to integrate an input current on one of a plurality of integration capacitors to generate an integrated voltage. A self-resetting continuous-time differentiator is configured to differentiate the integrated voltage on one of a plurality of differentiating capacitors to generate an output voltage proportional to the input current. A fixed-threshold window comparator is configured to reset one of the plurality of integration capacitors, reset one of the plurality of differentiating capacitors, open a second one of the plurality of integration capacitors and open a second one of the plurality of differentiating capacitors in response to the integrated voltage exceeding a voltage range.

High-speed molecular diagnostics

A complementary metal oxide semiconductor (CMOS)-integrated junction field effect transistor (JFET) has reduced scale and reduced noise. An exemplary JFET has a substrate layer of one dopant type with a gate layer of that dopant type disposed on the substrate, a depletion channel of a second dopant type disposed on the first gate layer, and a second gate layer of the first dopant type disposed on the depletion channel and proximate a surface of the transistor. The second gate layer can separate the depletion channel from the surface, and the depletion channel separates the first gate layer from the second gate layer.

Systems and methods for CMOS-integrated junction field effect transistors for dense and low-noise bioelectronic platforms

Growing community of inventors

Providence, RI, United States of America

Jacob Karl Rosenstein