St. Jude Medical, Cardiology Division, Inc.

St. Jude Medical, Inc.

St. Jude Medical International Holding S.a.r.l.

Jacob John Daly

Peter Nicholas Braido

Huisun Wang

Ralph Joseph Thomas

Aaron J Chalekian

Julia Ann Schraut

Troy Terrance Tegg

Yousef F Alkhatib

Derek C Sutermeister

Daniel Coyle

Bradley Charles Knippel

Ryan Kenneth Buesseler

Mary Johnson

Valerie J Glazier

Mina Safwat Fahim

Kent J Smith

Steven Frederick Anderl

Peter J Ness

Thomas M Benson

Brett Allen Hillukka

Jeffrey Michael Fish

Timothy S Marass

Thomas Alan Savard

Lakshya Mittal

John Tranter

Mary B Johnson

Daniel P Coyle

A method of assembling a prosthetic heart valve includes providing a collapsible and expandable stent having an annulus section and an aortic section. The annulus section has a first diameter in a relaxed condition and a second diameter less than the first diameter in a collapsed condition. A constraint is applied to the stent to constrain the annulus section to a predetermined diameter between the first and second diameters. Applying a cuff and/or a plurality of leaflets to the stent in the constrained condition enables less material to be used. The resultant prosthetic valve is therefore able to be collapsed to a smaller diameter for introduction into a patient.

Valve assembly method for crimp profile

A medical device, system, and method having a flexible shaft and a multi-core fiber within the flexible shaft. The multi-core fiber includes a plurality of optical cores dedicated for shape sensing sensors, and a plurality of optical cores dedicated for force sensing sensors. A tip assembly can comprise a tip electrode and a coupler comprising at least one fiber support tube center. A distal portion of the coupler can be coupled to a proximal portion of the tip electrode. The tip assembly can further comprise a multi-core fiber comprising a plurality of cores and a fiber support tube. A proximal portion of the fiber support tube can be coupled to the at least one fiber support tube center.

One fiber force and shape sensing

An elongate medical device comprising a first lumen, wherein a cross-sectional shape of the first lumen comprises a peanut shape, and a plurality of second lumens, wherein the plurality of second lumens are proximate the first lumen, wherein the first lumen comprises a lumen liner that conforms to the cross-sectional shape of the first lumen, wherein the lumen liner comprises a first material and the elongate medical device comprises a second material, where the first material is different from the second material.

Lumen management catheter

Valve assembly for crimp profile

A delivery device for a collapsible heart valve includes an operating handle and a catheter assembly. The operating handle includes a frame defining a movement space therein, a carriage assembly moveable in a longitudinal direction within the movement space, and a coupler having locked and unlocked conditions, the coupler being operatively connected to the carriage assembly for movement therewith. The catheter assembly includes a shaft around which a valve-receiving compartment is defined, the shaft being operatively connected to one of the frame or the carriage assembly, and a distal sheath operatively connected to the carriage assembly for movement therewith between a closed condition adapted to maintain the valve in the compartment and an open condition adapted to fully deploy the valve.

Staged deployment devices and methods for transcatheter heart valve delivery

A prosthetic heart valve includes a collapsible and expandable stent and a plurality of commissure features disposed on the stent. A collapsible and expandable valve assembly includes a plurality of leaflets connected to the plurality of commissure features, each commissure feature including a body having a proximal end and a distal end. A plurality of eyelets is arranged in rows and columns on the body for distributing load from the plurality of leaflets.

Leaflet attachment having tabs and flaps

A prosthetic heart valve may include a collapsible and expandable stent having a proximal end, a distal end, an annulus section adjacent the proximal end, and a plurality of cells connected to one another in annular rows around the stent, a cuff attached to the stent, and a sealing member attached to the cuff and extending from a proximal end of the cuff to a free edge. The sealing member may be movable between an extended condition in which the free edge is located proximally of the proximal end of the stent, and an inverted condition in which the free edge is located distally of the proximal end of the stent and a first surface of the sealing member confronts an outward-facing surface of the cuff. Various mechanisms for moving the sealing member are also described.

Paravalvular sealing via extended cuff mechanisms

A delivery devicefor a collapsible prosthetic heart valve includes a catheter assemblyincluding a shaftaround which a compartmentis defined, the compartmentbeing adapted to receive the valve in an assembled condition, and a retainerincluding a pusherand a holderadapted to retain a stent portionof the valve. The catheter assemblyalso includes a distal sheathadapted to selectively cover and uncover the compartmentand the valve, the distal sheathextending around the shaftat least when the distal sheathcovers the compartmentThe pusherincludes one or more recessesin a retention edgethereof, each recessbeing adapted to receive a junctionat an end of the stent portionof the valve. The holderincludes one or more elongated ribseach ribbeing adapted to fit into a cell openingof the stent portionof the valve.

Retainers for transcatheter heart valve delivery systems

An introducer provides access to a surgical site in a patient. The introducer includes a proximal housing configured to be positioned outside the patient and a sheath extending from the proximal housing to a distal end of the introducer. One or more handles may be housed at least partially within the proximal housing and configured to translate axially in proximal and distal directions with respect to the proximal housing. A securing element may be slideably coupled to the sheath and may have a flange extending radially outwardly from the sheath. A radially expanding portion of the sheath may have a first edge, a second edge, and a middle section extending from the first edge to the second edge. The sheath portion may have a rolled configuration in which the middle section at least partially overlies the first edge, and the second edge at least partially overlies the middle section.

Transcatheter valve implantation access sheaths

A delivery device for a collapsible medical device may include a handle and a delivery assembly having a compartment for receiving the medical device. A catheter member may extend from the handle to the delivery assembly. The catheter member may have a first portion with a first compliance value and a second portion with a second compliance value different from the first compliance value. An internally threaded member may be fixedly connected to the delivery assembly. An externally threaded member may have a first portion operatively connected to the actuation member and a second portion threadedly coupled to the internally threaded member so that manipulation of the actuation member causes axial movement of the compartment relative to the catheter member.

Basket delivery system

A device for repositioning an implant within a lumen of a subject including (a) a catheter having forward and rearward ends and a collapsible and expansible stop element mounted adjacent the forward end of the catheter, the stop element being adapted to engage a wall of the lumen when expanded and to provide one or more passages extending from a rear side of the stop element to a forward side of the stop element when the stop element is expanded and engaged with the wall of the lumen and (b) one or more snares, each snare having engagement features, the stop element and the snares being constructed and arranged so that the snares can be positioned extending through the one or more passages with their engagement features forward of the stop element.

Methods of repositioning a transcatheter heart valve after full deployment

Staged development devices and methods for transcatheter heart valve delivery

A prosthetic heart valvemay include a collapsible and expandable stenthaving a proximal end, a distal end, an annulus section adjacent the proximal end, and a plurality of cells connected to one another in annular rows around the stent, a cuffattached to the stent, and a sealing memberattached to the cuff and extending from a proximal endof the cuff to a free edge. The sealing membermay be movable between an extended condition in which the free edgeis located proximally of the proximal endof the stent, and an inverted condition in which the free edge is located distally of the proximal end of the stent and a first surfaceof the sealing member confronts an outward-facing surface of the cuff. Various mechanisms for moving the sealing memberare also described.

A delivery device () for an implantable medical device includes an inner shaft () extending in a longitudinal direction and defining a compartment () adapted to receive the medical device in an assembled condition, an outer shaft () surrounding a longitudinal portion of the inner shaft, and a distal sheath () operatively attached to the outer shaft (). The distal sheath () is slidable between a first position enclosing the compartment () and a second position exposing the compartment () for deployment of the medical device. A sleevesurrounds at least a longitudinal portion of the outer shaft () and provides a substantially blood tight bearing surface that facilitates sliding movement of the delivery device () in an introducer ().

Growing community of inventors

Blaine, MN, United States of America

Jacob John Daly