University of Washington

University of Utah Research Foundation

Jacob Bale

David Baker

Neil P King

William H Sheffler

Daniel Ellis

Marc J Lajoie

Wesley Sundquist

Elizabeth Gray

Daniel Stetson

Yang Hsia

Joerg Votteler

Gabriel Butterfield

Synthetic nanostructures, polypeptides that are useful, for example, in making synthetic nanostructures, and methods for using such synthetic nanostructures are disclosed herein.

Polypeptides for use in self-assembling protein nanostructures

The application discloses multimeric assemblies including multiple oligomeric substructures, where each oligomeric substructure includes multiple proteins that self-interact around at least one axis of rotational symmetry, where each protein includes one or more polypeptide-polypeptide interface ('O interface'); and one or more polypeptide domain that is capable of effecting membrane scission and release of an enveloped multimeric assembly from a cell by recruiting the ESCRT machinery to the site of budding by binding to one or more proteins in the eukaryotic ESCRT complex ('L domain'); and where the multimeric assembly includes one or more subunits comprising one or more polypeptide domain that is capable of interacting with a lipid bilayer (&#x201c;M domain&#x201d;), as well as membrane-enveloped versions of the multimeric assemblies.

Polypeptide assemblies and methods for the production thereof

Synthetic nanostructures, proteins that are useful, for example, in making synthetic nanostructures, and methods for designing such synthetic nanostructures are disclosed herein.

Self-assembling protein nanostructures

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Seattle, WA, United States of America

Jacob Bale