Case Western Reserve University

Jacob Antunes

Anant Madabhushi

Satish E Viswanath

Pallavi Tiwari

Zhouping Wei

Charlems Alvarez Jimenez

The present disclosure, in some embodiments, relates to a non-transitory computer-readable medium storing computer-executable instructions. The computer readable medium is configured to cause a processor to access an image volume of a rectum comprising a rectal tumor. A forward mapping is generated based on non-rigidly registering a healthy rectal atlas to the image volume. The forward mapping is inverted to generate an inverse mapping from the image volume to the healthy rectal atlas. Based on the inverse mapping, a plurality of deformation vectors, associated with a deformation within a rectal wall of the rectum, are determined. Magnitude based deformation features and orientation based deformation features are computed from the plurality of deformation vectors. One or more of the magnitude based deformation features and one or more of the orientation based deformation features are utilized to determine a response of a patient to a chemoradiation treatment.

Structural rectal atlas deformation features for characterizing intra-wall and peri-wall chemoradiation response on magnetic resonance imaging (MRI)

Embodiments discussed herein facilitate determination of responsiveness to chemoradiation treatment in rectal cancer patients based on structural deformation features obtained from a pre- or post-treatment medical imaging. One example embodiment can perform operations comprising: accessing an image volume of a rectum comprising a rectal tumor; generating a forward mapping based on non-rigidly registering a healthy rectal atlas to the image volume; inverting the forward mapping to generate an inverse mapping from the image volume to the healthy rectal atlas; determining, based on the inverse mapping, an associated deformation magnitude for each voxel of a plurality of voxels associated with the rectum; computing one or more structural deformation features based on the associated deformation magnitudes for the plurality of voxels; and predicting via a classifier whether or not the rectal tumor will respond to the chemoradiation treatment based at least in part on the one or more structural deformation features.

Methods and apparatus associated with predicting colorectal cancer tumor invasiveness are described. One example apparatus includes a set of circuits, and a data store that stores radiological images of tissue demonstrating colorectal cancer. The set of circuits includes a circumferential resection margin (CRM) prediction circuit that generates a CRM probability score for a diagnostic radiological image, an image acquisition circuit that acquires a diagnostic radiological image of a region of tissue demonstrating colorectal cancer pathology and that provides the diagnostic radiological image to the CRM prediction circuit, and a training circuit that trains the CRM prediction circuit to quantify chemoradiation response in the region of tissue represented in the diagnostic radiological image. The training circuit trains the CRM prediction circuit using a set of composite images.

Treatment planning and evaluation for rectal cancer via image analytics

Embodiments access an image of a region of interest (ROI) demonstrating cancerous pathology; extract radiomic features from the ROI; define a radiomic feature expression scene based on the ROI and radiomic features; generate a cluster map by superpixel clustering the expression scene; generate an expression map by repartitioning the cluster map into expression levels; compute a textural and spatial phenotypes for the expression map based on the expression levels; construct a radiomic spatial textural (RADISTAT) descriptor by concatenating the textural and spatial phenotypes; provide the RADISTAT descriptor to a machine learning classifier; receive, from the machine learning classifier, a first probability that the ROI is a responder or non-responder, or a second probability that the ROI will experience long-term survival or short-term survival, based, at least in part, on the RADISTAT descriptor; and generate a classification of the ROI as a responder or non-responder, or long-term survivor or short-term survivor.

Growing community of inventors

Cincinnati, OH, United States of America

Jacob Antunes